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<p>Hexamerins, traditionally defined as hemolymph-based, high-molecular-weight storage proteins that provide essential amino acids and energy for non-feeding insect stages, are increasingly recognized as multifunctional, versatile proteins. Recent research highlighted their involvement in hormone transport, caste polyphenism, immunity, reproduction, gut regeneration &amp; plastic bioremediation. Hexamerins are actively synthesized by the larval fat body and secreted out into the insect hemolymph. Conventionally, these proteins are hydrolysed and sequestered back into the fat body for tissue remodelling during the non-feeding pupal and pharate adult stages. Hexamerins are also actively sequestered by male accessory reproductive glands (MARG), salivary glands and ovaries in various insect species. In this study, we demonstrated the sequestration of fluorescent-labelled hexamerin-enriched protein fraction (HEPF) by larval gut during Cry toxin-induced cell proliferation monitored by Bromodeoxyuridine (BrdU) labelling in <i>Achaea janata</i>. This finding would add a new dimension to the ongoing studies involved in deciphering mechanisms of field-evolved Bt resistance being reported in various insects worldwide.</p>

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Hexamerin-enriched protein sequestration by Achaea janata larval midgut during Cry toxin-induced regenerative cell proliferation

  • 期刊论文

  • 发表日期：

    2026年8月4日

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  • Arindam Hatimuria,
  • Jahid Hossain Mollah,
  • Narender K. Dhania,
  • Chaitanya R.K.,
  • Vinod K. Chauhan

摘要

Hexamerins, traditionally defined as hemolymph-based, high-molecular-weight storage proteins that provide essential amino acids and energy for non-feeding insect stages, are increasingly recognized as multifunctional, versatile proteins. Recent research highlighted their involvement in hormone transport, caste polyphenism, immunity, reproduction, gut regeneration & plastic bioremediation. Hexamerins are actively synthesized by the larval fat body and secreted out into the insect hemolymph. Conventionally, these proteins are hydrolysed and sequestered back into the fat body for tissue remodelling during the non-feeding pupal and pharate adult stages. Hexamerins are also actively sequestered by male accessory reproductive glands (MARG), salivary glands and ovaries in various insect species. In this study, we demonstrated the sequestration of fluorescent-labelled hexamerin-enriched protein fraction (HEPF) by larval gut during Cry toxin-induced cell proliferation monitored by Bromodeoxyuridine (BrdU) labelling in Achaea janata. This finding would add a new dimension to the ongoing studies involved in deciphering mechanisms of field-evolved Bt resistance being reported in various insects worldwide.