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<p>Vector control remains the main strategy to reduce <i>Trypanosoma cruzi</i> transmission, particularly in endemic areas where <i>Rhodnius prolixus</i> is a primary vector. However, the intensive use of pyrethroids has led to the emergence of resistant populations, highlighting the need for new insecticidal technologies. The present study evaluated the efficacy of a novel fipronil oily film formulation based on poly(vinyl alcohol) and a sunflower oil–Tween 80 vehicle. Formulations with one- and two-part oil contents were applied to glass and filter paper surfaces, and fifth-instar <i>R. prolixus</i> nymphs were exposed to four fipronil doses (0.4–4.0&#xa0;g m⁻²). Mortality was recorded at 24, 48, and 72&#xa0;h, and topical bioassays were performed to estimate lethal doses. All formulations produced stable films. While both formulations achieved 100% mortality on glass surfaces, efficacy on filter paper was lower and dose-dependent, with the highest values recorded at 72&#xa0;h, indicating a delayed lethal effect. The one-part oil formulation showed significantly higher mortality than the two-part oil formulation. Topical assays yielded an LD₅₀ of 285 ng/insect (95% CI: 176–464) and an LD₉₀ of 2286 ng/insect (95% CI: 1172–7799). These results support the potential of oily film-based fipronil formulations as a promising alternative technology for the control of <i>R. prolixus</i>.</p>

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Insecticidal efficacy of a fipronil oily film formulation with surface-localized delivery against Rhodnius prolixus (Hemiptera: Reduviidae), a vector of Chagas disease

  • 期刊论文

  • 发表日期：

    2026年6月18日

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  • Federico Karp,
  • Patricia A. Lobbia,
  • Sofía Trusso Sierocinski,
  • Agustín Balsalobre,
  • Luciano N. Mengatto,
  • Germán A. Islan,
  • Gerardo A. Marti

摘要

Vector control remains the main strategy to reduce Trypanosoma cruzi transmission, particularly in endemic areas where Rhodnius prolixus is a primary vector. However, the intensive use of pyrethroids has led to the emergence of resistant populations, highlighting the need for new insecticidal technologies. The present study evaluated the efficacy of a novel fipronil oily film formulation based on poly(vinyl alcohol) and a sunflower oil–Tween 80 vehicle. Formulations with one- and two-part oil contents were applied to glass and filter paper surfaces, and fifth-instar R. prolixus nymphs were exposed to four fipronil doses (0.4–4.0 g m⁻²). Mortality was recorded at 24, 48, and 72 h, and topical bioassays were performed to estimate lethal doses. All formulations produced stable films. While both formulations achieved 100% mortality on glass surfaces, efficacy on filter paper was lower and dose-dependent, with the highest values recorded at 72 h, indicating a delayed lethal effect. The one-part oil formulation showed significantly higher mortality than the two-part oil formulation. Topical assays yielded an LD₅₀ of 285 ng/insect (95% CI: 176–464) and an LD₉₀ of 2286 ng/insect (95% CI: 1172–7799). These results support the potential of oily film-based fipronil formulations as a promising alternative technology for the control of R. prolixus.