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<p>Millions of people die each year from diseases that mosquitoes transmit and pass on to humans. Because of the lack of broad awareness, the emergence of resistance, and socioeconomic factors, mosquito control is a major challenge in emerging nations like India. Most frequently, chemical pesticides are employed to control the <i>Aedes aegypti</i> population. High costs and the evolution of resistant populations against such chemical insecticides are the results of their unchecked use. In light of this, there is a need for the screening of novel mosquito larvicidal compounds that could take the place of commercial insecticides. Pyridocoumarin, often known as pyranoquinoline, is a class of heterocyclic compound with medical importances i.e. antitumour, anti-alzheimer agent. There are no reports of pyridocoumarin being used as larvicides against mosquito larvae. Two pyrano[3,2-f]quinolin-3-one derivatives, 3&#xa0;H-pyrano[3,2-f]quinolin-3-one (<b>PQ</b>) and 8-methyl-3&#xa0;H-pyrano[3,2-f]quinolin-3-one (<b>MPQ</b>) have been synthesized and the mosquito larvicidal activity of these compounds have been examined against 3rd instar larvae of <i>Ae. aegypti</i>. These two compounds are planner, tricyclic, conjugated heterocyles. These compounds are special class of pyrano quinoline heterocycles derived from natural product coumarin. There is plenty of bioactivity of these classes of molecules but there is no literature precedent of pesticide or larvicidal activity of this class of molecules before our investigation. Both the compounds exhibit potential mosquito larvicidal activity against 3rd instar larvae of <i>Ae. aegypti.</i> They reduce the viability of mosquito larvae in a dose dependent manner. 3&#xa0;H-pyrano[3,2-f]quinolin-3-one (<b>PQ</b>) (LC<sub>50</sub>: 125.29&#xa0;µg/ml) exhibits higher efficacy compared to 8-methyl-3&#xa0;H-pyrano[3,2-f]quinolin-3-one (<b>MPQ</b>) (LC<sub>50</sub>: 146.88&#xa0;µg/ml). These compounds induce structural and morphological damages to mosquito larvae. Both the compounds increase ROS accumulation dose dependently in <i>Ae. aegypti</i> larvae. Increased ROS accumulation within the mosquito larvae may be the cause of larval death.</p> Graphical Abstract <p></p>

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Comparative analysis of mosquito larvicidal activity of Pyrano [3,2-f] quinolin-3-one derivatives against Aedes aegypti through generation of reactive oxygen species

  • 期刊论文

  • 发表日期：

    2025年5月27日

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  • Pamela Pal,
  • Swarupa Mondal,
  • Monalisa Pramanik,
  • Biplab Bhowmik,
  • Tapas Ghosh,
  • Tanmay Chattopadhyay,
  • Raj Kumar Nandi,
  • Priya Roy

摘要

Millions of people die each year from diseases that mosquitoes transmit and pass on to humans. Because of the lack of broad awareness, the emergence of resistance, and socioeconomic factors, mosquito control is a major challenge in emerging nations like India. Most frequently, chemical pesticides are employed to control the Aedes aegypti population. High costs and the evolution of resistant populations against such chemical insecticides are the results of their unchecked use. In light of this, there is a need for the screening of novel mosquito larvicidal compounds that could take the place of commercial insecticides. Pyridocoumarin, often known as pyranoquinoline, is a class of heterocyclic compound with medical importances i.e. antitumour, anti-alzheimer agent. There are no reports of pyridocoumarin being used as larvicides against mosquito larvae. Two pyrano[3,2-f]quinolin-3-one derivatives, 3 H-pyrano[3,2-f]quinolin-3-one (PQ) and 8-methyl-3 H-pyrano[3,2-f]quinolin-3-one (MPQ) have been synthesized and the mosquito larvicidal activity of these compounds have been examined against 3rd instar larvae of Ae. aegypti. These two compounds are planner, tricyclic, conjugated heterocyles. These compounds are special class of pyrano quinoline heterocycles derived from natural product coumarin. There is plenty of bioactivity of these classes of molecules but there is no literature precedent of pesticide or larvicidal activity of this class of molecules before our investigation. Both the compounds exhibit potential mosquito larvicidal activity against 3rd instar larvae of Ae. aegypti. They reduce the viability of mosquito larvae in a dose dependent manner. 3 H-pyrano[3,2-f]quinolin-3-one (PQ) (LC50: 125.29 µg/ml) exhibits higher efficacy compared to 8-methyl-3 H-pyrano[3,2-f]quinolin-3-one (MPQ) (LC50: 146.88 µg/ml). These compounds induce structural and morphological damages to mosquito larvae. Both the compounds increase ROS accumulation dose dependently in Ae. aegypti larvae. Increased ROS accumulation within the mosquito larvae may be the cause of larval death.

Graphical Abstract