<p>The common house fly, <i>Musca domestica</i> L., is a global ubiquitous pest with significant implications for both medical and veterinary fields. Traditional insecticide-based approaches have encountered challenges due to the <i>M. domestica</i> ability to develop resistance. This study seeks to uncover the effects, both sublethal and lethal, of chloroxylenol on various fitness parameters of <i>M. domestica</i> populations over two consecutive generations, thereby endorsing its possible inclusion in Integrated Pest Management (IPM) strategies. It’s worth noting that chloroxylenol is already present in our markets, serving as a disinfectant in households and healthcare facilities as well as related institutional spaces. The study revealed substantial impacts on key parameters, such as pupal weight, adult emergence (%) as well as the rate of pupation (%). Notably, significant reductions were observed in populations exposed to five different chloroxylenol concentrations (1, 5, 10, 20, 40 ppm) compared to the control group, spanning two generations (F₀ and F₁). The bioassay further confirmed a concentration-dependent pattern, where the highest chloroxylenol concentration led to extended developmental durations across all life stages (egg, larva, pupa), thus lengthening the overall development timeline of <i>M. domestica</i>. Chloroxylenol also had discernible effects on egg hatching (%) and fecundity (egg laying capacity), all of which were notably reduced in the offspring generation of <i>M. domestica</i> compared to the control group. In conclusion, the results of this study suggest that chloroxylenol holds promise as an alternative to traditional insecticides, highlighting its potential for integration into IPM programs aimed at controlling <i>M. domestica</i> populations.</p>