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Purpose <p>To investigate the effects of Acoustic Non-Periodic Stimulation (ANPS) on the synchronization dynamics of brain functional networks (BFNs) and the quality of life (QoL) in patients with drug-resistant epilepsy (DRE).</p> Methods <p>brain functional networks (BFN) were generated from electroencephalogram (EEG) data using the motif synchronization association method. The analysis focused on changes in functional connectivity, variability of brain network topological measures, and patient-reported QoL.</p> Results <p>Functional connectivity revealed a significant reduction during the acute treatment phase, followed by an increase on the fifth day prior to re-stimulation. Increased variability in path length and betweenness centrality was observed, while critical network hubs were maintained. QoL demonstrated significant improvements, particularly in cognitive and social functioning domains.</p> Conclusion <p>ANPS appears to promote brain network reorganization, reflected in altered synchronization dynamics and topological measures, which may explain the observed QoL improvements. These findings suggest ANPS as a promising alternative for managing DRE. Future research should further explore the topological variability associated with this stimulation modality.</p>

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Effect of the acoustic non-periodic stimulus on functional networks of cerebral synchrony in epilepsy

  • 期刊论文

  • 发表日期：

    2025年11月10日

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  • Tandara Oliveira Benevides Silva,
  • Marilia Marinho de Lucena,
  • Eslaine Santos e Santos,
  • Marcelo Cairrão Araujo Rodrigues,
  • Wellington Pinheiro dos Santos,
  • José Garcia Vivas Miranda,
  • Eduardo Pondé de Sena

摘要

Purpose

To investigate the effects of Acoustic Non-Periodic Stimulation (ANPS) on the synchronization dynamics of brain functional networks (BFNs) and the quality of life (QoL) in patients with drug-resistant epilepsy (DRE).

Methods

brain functional networks (BFN) were generated from electroencephalogram (EEG) data using the motif synchronization association method. The analysis focused on changes in functional connectivity, variability of brain network topological measures, and patient-reported QoL.

Results

Functional connectivity revealed a significant reduction during the acute treatment phase, followed by an increase on the fifth day prior to re-stimulation. Increased variability in path length and betweenness centrality was observed, while critical network hubs were maintained. QoL demonstrated significant improvements, particularly in cognitive and social functioning domains.

Conclusion

ANPS appears to promote brain network reorganization, reflected in altered synchronization dynamics and topological measures, which may explain the observed QoL improvements. These findings suggest ANPS as a promising alternative for managing DRE. Future research should further explore the topological variability associated with this stimulation modality.