Scholarlink

<p>Microbial resistance is a growing global public health problem, intensified by the misuse of synthetic drugs, leading to the search for biologically active compounds or antibiotic adjuvants to combat bacterial resistance. The plant <i>Himatanthus drasticus</i> (Mart.) Plumel, commonly used by residents of Chapada do Araripe for medicinal purposes, has attracted interest in this context. This study aimed to determine the phytochemical composition of methanolic and hexane extracts from the stem bark of <i>H. drasticus</i> and evaluate their antibacterial and drug-potentiating effects, along with an in vivo toxicity analysis. Phytochemical screening identified nine secondary metabolites, five of which were flavonoids. Antibacterial tests, including MIC determination against <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, and <i>Pseudomonas aeruginosa</i>, showed no direct antibacterial activity. However, when combined with norfloxacin, both extracts enhanced the antibiotic’s action against <i>S. aureus</i>. In contrast, the methanolic extract reduced the efficacy of oxacillin against <i>E. coli</i> and <i>S. aureus</i>, while the hexane extract diminished gentamicin’s effectiveness and increased norfloxacin’s MIC against <i>P. aeruginosa</i>. Toxicity assessments in <i>Drosophila melanogaster</i> and <i>Artemia salina</i> showed mild toxicity for the hexane extract at higher concentrations, while the methanolic extract was considered non-toxic. Overall, <i>H. drasticus</i> extracts exhibit potential as drug potentiators against resistant bacteria, with low toxicity.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Himatanthus drasticus (Mart.) Plumel (APOCYNACEAE): phytochemical profile, evaluation of antibacterial and drug-potentiating activity, and toxicity of stem bark extracts

  • 期刊论文

  • 发表日期：

    2026年5月23日

查看全文
  • Maraiza Gregorio de Oliveira,
  • Adrielle Rodrigues Costa,
  • Jailson Renato de Lima Silva,
  • Carlos Alonso leite dos Santos,
  • Ana Raquel Pereira da Silva,
  • Daniel Sampaio Alves,
  • José Weverton Almeida-Bezerra,
  • Ademar Maia Filho,
  • José Walber Gonçalves Castro,
  • Bárbara Fernandes Melo,
  • Francisca de Fátima Silva de Sousa,
  • Marcos Santos,
  • Lariza Leisla Leandro Nascimento,
  • Maria Audilene de Freitas,
  • Nara Juliana Santos Araújo,
  • Severino Denicio Gonçalves de Sousa,
  • Luiz Filipi Teles Feitosa,
  • Janaína Esmeraldo Rocha,
  • Henrique Douglas Melo Coutinho,
  • Antonia Eliene Duarte,
  • Luiz Marivando Barros

摘要

Microbial resistance is a growing global public health problem, intensified by the misuse of synthetic drugs, leading to the search for biologically active compounds or antibiotic adjuvants to combat bacterial resistance. The plant Himatanthus drasticus (Mart.) Plumel, commonly used by residents of Chapada do Araripe for medicinal purposes, has attracted interest in this context. This study aimed to determine the phytochemical composition of methanolic and hexane extracts from the stem bark of H. drasticus and evaluate their antibacterial and drug-potentiating effects, along with an in vivo toxicity analysis. Phytochemical screening identified nine secondary metabolites, five of which were flavonoids. Antibacterial tests, including MIC determination against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, showed no direct antibacterial activity. However, when combined with norfloxacin, both extracts enhanced the antibiotic’s action against S. aureus. In contrast, the methanolic extract reduced the efficacy of oxacillin against E. coli and S. aureus, while the hexane extract diminished gentamicin’s effectiveness and increased norfloxacin’s MIC against P. aeruginosa. Toxicity assessments in Drosophila melanogaster and Artemia salina showed mild toxicity for the hexane extract at higher concentrations, while the methanolic extract was considered non-toxic. Overall, H. drasticus extracts exhibit potential as drug potentiators against resistant bacteria, with low toxicity.