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<p><i>Neptunia oleracea</i> Lour., commonly known as “Yellow Pan Weed, Water Mimosa or Water Sensitive Plant”, is a wild aquatic plant of the genus <i>Neptunia</i> in the family Fabaceae, and its parts can be used as food and in medicine. With further exploration, its applications are found in various fields, including food, agriculture, and medicinal herbs. This review summarizes traditional knowledge by integrating it with scientific evidence related to <i>N. oleracea</i>’s phytochemical compounds, pharmacological activities, and therapeutic potential. This narrative review analyzed 50 documents from databases, including Web of Science, Scopus, Google Scholar, ScienceDirect, SpringerLink, PubMed, and other online databases (1790–2025), focusing on articles and textbooks on <i>N. oleracea</i>’s botany, nutritional benefits, traditional uses, phytochemistry, and pharmacological properties. 54 metabolites, including pheophorbides, phenolics, flavonoids, and other compounds, were found in <i>N. oleracea</i>. The extracts from <i>N. oleracea</i> parts and its isolated compounds have been shown to possess various biological properties, including antioxidant, antimicrobial, anti‐inflammatory, analgesic, anticancer, antiulcer, astringent, anti-5<i>α</i>-reductase, and anti-diabetic activities. These pharmacological properties are closely associated with the presence of phenolic compounds, particularly flavonoids. Various parts of <i>N. oleracea</i> contain nutritional components, minerals, and vitamins. Although some evidence supports the link between traditional uses and modern pharmacology, significant knowledge gaps still hinder its integration into evidence-based clinical applications. In the future, prioritizing large-scale clinical studies and developing combination formulations will further elucidate and expand the therapeutic potential of <i>N. oleracea</i>.</p>

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Neptunia oleracea Lour. (Fabaceae): a literature review on nutritional benefits, ethnomedicine, phytochemistry, pharmacology, and toxicology

  • 期刊论文

  • 发表日期：

    2026年5月19日

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  • Tran Van Chen,
  • Hua Thanh Truong Thinh,
  • Nguyen Van Truong Sanh,
  • Tran Viet Dang Khoa,
  • Duong Nguyen Xuan Lam,
  • Tien V. T. Nguyen,
  • Thawatphong Boonma,
  • Vo Trong Tuan

摘要

Neptunia oleracea Lour., commonly known as “Yellow Pan Weed, Water Mimosa or Water Sensitive Plant”, is a wild aquatic plant of the genus Neptunia in the family Fabaceae, and its parts can be used as food and in medicine. With further exploration, its applications are found in various fields, including food, agriculture, and medicinal herbs. This review summarizes traditional knowledge by integrating it with scientific evidence related to N. oleracea’s phytochemical compounds, pharmacological activities, and therapeutic potential. This narrative review analyzed 50 documents from databases, including Web of Science, Scopus, Google Scholar, ScienceDirect, SpringerLink, PubMed, and other online databases (1790–2025), focusing on articles and textbooks on N. oleracea’s botany, nutritional benefits, traditional uses, phytochemistry, and pharmacological properties. 54 metabolites, including pheophorbides, phenolics, flavonoids, and other compounds, were found in N. oleracea. The extracts from N. oleracea parts and its isolated compounds have been shown to possess various biological properties, including antioxidant, antimicrobial, anti‐inflammatory, analgesic, anticancer, antiulcer, astringent, anti-5α-reductase, and anti-diabetic activities. These pharmacological properties are closely associated with the presence of phenolic compounds, particularly flavonoids. Various parts of N. oleracea contain nutritional components, minerals, and vitamins. Although some evidence supports the link between traditional uses and modern pharmacology, significant knowledge gaps still hinder its integration into evidence-based clinical applications. In the future, prioritizing large-scale clinical studies and developing combination formulations will further elucidate and expand the therapeutic potential of N. oleracea.