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<p><i>Nothapodytes nimmoniana</i>, an endangered medicinal plant from Assam, India, holds immense promise beyond its well-known bark-derived compounds. This study delves into the untapped potential of its leaves by unveiling their rich phytochemical profile, robust antioxidant activity, and diverse mineral composition. Methanolic extraction yielded 11.24%, with qualitative screening revealing a wide array of bioactive constituents, including alkaloids, phenols, flavonoids, saponins, steroids, tannins, proteins, carbohydrates, and glycosides. Impressively, the total phenolic and flavonoid contents measured 31.80 ± 0.15&#xa0;mg Gallic Acid Equivalent (GAE/g) and 5.52 ± 0.08&#xa0;mg Quercetin Equivalent (QE/g), respectively. The extract exhibited remarkable free radical scavenging efficiency, demonstrated by a low IC₅₀ of 1.28&#xa0;µg/ml in the <i>“(1,1-diphenyl-2-picrylhydrazyl (DPPH</i>)” assay, alongside potent “<i>2, 2′-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS)</i>”, nitric oxide, and hydroxyl radical neutralizing activities. LC–MS analysis identified nine significant compounds, including 5-hydroxy 9-methoxy camptothecin, enoxolone, gypsogenin, and 2-demethylmenaquinol-8, underscoring its chemotherapeutic potential. Additionally, potassium emerged as the most abundant mineral (42.94&#xa0;ppm), enriching its nutraceutical value. Altogether, this research positions <i>N. nimmoniana</i> leaves as a promising, sustainable source for antioxidant-rich, plant-based drug discovery, offering a compelling alternative to bark harvesting and contributing to conservation efforts.</p> Graphical abstract <p></p>

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Comprehensive insight into the phytochemical profile, antioxidant properties, and LC-MS analysis of methanolic leaf extract of Nothapodytes nimmoniana (J. Graham) Mabb., a medicinal plant of Assam, India

  • 期刊论文

  • 发表日期：

    2025年11月20日

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  • Rubina Ahmed,
  • Raihana Yashmin,
  • Jogen Chandra Kalita

摘要

Nothapodytes nimmoniana, an endangered medicinal plant from Assam, India, holds immense promise beyond its well-known bark-derived compounds. This study delves into the untapped potential of its leaves by unveiling their rich phytochemical profile, robust antioxidant activity, and diverse mineral composition. Methanolic extraction yielded 11.24%, with qualitative screening revealing a wide array of bioactive constituents, including alkaloids, phenols, flavonoids, saponins, steroids, tannins, proteins, carbohydrates, and glycosides. Impressively, the total phenolic and flavonoid contents measured 31.80 ± 0.15 mg Gallic Acid Equivalent (GAE/g) and 5.52 ± 0.08 mg Quercetin Equivalent (QE/g), respectively. The extract exhibited remarkable free radical scavenging efficiency, demonstrated by a low IC₅₀ of 1.28 µg/ml in the “(1,1-diphenyl-2-picrylhydrazyl (DPPH)” assay, alongside potent “2, 2′-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS)”, nitric oxide, and hydroxyl radical neutralizing activities. LC–MS analysis identified nine significant compounds, including 5-hydroxy 9-methoxy camptothecin, enoxolone, gypsogenin, and 2-demethylmenaquinol-8, underscoring its chemotherapeutic potential. Additionally, potassium emerged as the most abundant mineral (42.94 ppm), enriching its nutraceutical value. Altogether, this research positions N. nimmoniana leaves as a promising, sustainable source for antioxidant-rich, plant-based drug discovery, offering a compelling alternative to bark harvesting and contributing to conservation efforts.

Graphical abstract