Scholarlink

<p>An endophytic fungus <i>Xylaria feejeensis</i> was isolated from the leaves of <i>Cardiospermum halicacabum</i> and identified using molecular means. The fungus was cultured on a large scale in potato dextrose broth medium. After 4 weeks, the fungal media and mycelium were extracted with ethyl acetate and subjected to chromatographic separation furnished eight compounds namely, (<i>R</i>)-(-)-5-methoxycarbonylmellein (<b>1</b>), (<i>S</i>)-(+)-mellein (<b>2</b>), (<i>S</i>)-(+)-<i>O</i>-methylmellein (<b>3</b>), cycloepoxytriol A (<b>4</b>), 2-hydroxy-5-methoxy-3-methylcyclohexa-2,5-diene-1,4-dione (<b>5</b>), 2-chloro-5-methoxy-3-methylcyclohexa-2,5-diene-1,4-dione (<b>6</b>), phomopsiketone B (<b>7</b>) and 6-(1-hydroxypentyl)-4-methoxy-2<i>H</i>-pyran-2-one (<b>8</b>). Compounds <b>4</b> and <b>6</b> were isolated from the endophytic fungus <i>X. feejeensis</i> for the first time. Compound <b>1</b> exhibited α-glucosidase inhibitory activity with an IC<sub>50</sub> value of 46.54 ± 8.08 µM, which was significantly lower than that of the positive control acarbose.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Enzyme inhibitors from endophytic Xylaria feejeensis isolated from Cardiospermum halicacabum

  • 期刊论文

  • 发表日期：

    2025年9月16日

查看全文
  • Upesha Siriwardhane,
  • Kavindya Samarakoon,
  • Jayani Kalinga,
  • Deepthi Yakandawala,
  • Nimal Adikaram,
  • Lalith Jayasinghe,
  • Hiroshi Araya,
  • Yoshinori Fujimoto

摘要

An endophytic fungus Xylaria feejeensis was isolated from the leaves of Cardiospermum halicacabum and identified using molecular means. The fungus was cultured on a large scale in potato dextrose broth medium. After 4 weeks, the fungal media and mycelium were extracted with ethyl acetate and subjected to chromatographic separation furnished eight compounds namely, (R)-(-)-5-methoxycarbonylmellein (1), (S)-(+)-mellein (2), (S)-(+)-O-methylmellein (3), cycloepoxytriol A (4), 2-hydroxy-5-methoxy-3-methylcyclohexa-2,5-diene-1,4-dione (5), 2-chloro-5-methoxy-3-methylcyclohexa-2,5-diene-1,4-dione (6), phomopsiketone B (7) and 6-(1-hydroxypentyl)-4-methoxy-2H-pyran-2-one (8). Compounds 4 and 6 were isolated from the endophytic fungus X. feejeensis for the first time. Compound 1 exhibited α-glucosidase inhibitory activity with an IC50 value of 46.54 ± 8.08 µM, which was significantly lower than that of the positive control acarbose.