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<p>Diabetes mellitus is a chronic metabolic disease and is one of the leading causes of morbidity and mortality. The discovery of an effective and safe treatment is therefore very vital. This study aimed to determine the effect of freeze-dried herbal <i>Kaempferia galanga</i> extract supplementation (KGE) on hyperglycemia-induced dyslipidemia; altered biochemical, hematological, and histopathological parameters in STZ-induced BALB/c diabetic mice. In this study, it was observed that the treatment of STZ-induced diabetic mice with herbal KGE prevents hyperglycemia-induced dyslipidemia. Additionally, herbal KGE supplementation corrects the impaired glucose tolerance in diabetic mice. Herbal KGE supplementation improves altered biochemical parameters, such as liver and kidney function. Hematological analysis showed normalization of various altered blood indices in diabetic mice treated with herbal KGE. Furthermore, histopathological analysis of hepatocytes, cardiac, and renal tissue revealed regeneration and normalization upon herbal KGE supplementation following damage by STZ-induced hyperglycemia. Electron microscopy analysis of erythrocytes also revealed that herbal KGE supplementation had a protective effect on erythrocyte morphology. Inductively coupled plasma-optical emission spectroscopy (ICP-OES) analysis revealed the presence of various essential trace and major elements. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) phytochemical profiling analysis of herbal KGE revealed the presence of various compounds, such as flavonoids, polyphenols, alkaloids, coumaric acid, organic acid, and vitamins, which might be responsible for their anti-hyperglycemic and anti-hyperlipidemic activities with ethyl-p-methoxy-cinnamate (EPMC) as the major bioactive component. Therefore, from this study, it is observed that supplementation of diabetic mice with herbal KGE improved hyperglycemia-induced dyslipidemia and glucose tolerance while simultaneously provided tissue/cell protection against the damage caused by STZ-induced hyperglycemia.</p>

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Pharmacological and pathological ameliorating effect of freeze-dried Kaempferia galanga herbal supplementation on hyperglycemia-induced dyslipidemia in Balb/c diabetic mice

  • 期刊论文

  • 发表日期：

    2025年6月2日

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  • Flavius Phrangsngi Nonglang,
  • Surya Bhan

摘要

Diabetes mellitus is a chronic metabolic disease and is one of the leading causes of morbidity and mortality. The discovery of an effective and safe treatment is therefore very vital. This study aimed to determine the effect of freeze-dried herbal Kaempferia galanga extract supplementation (KGE) on hyperglycemia-induced dyslipidemia; altered biochemical, hematological, and histopathological parameters in STZ-induced BALB/c diabetic mice. In this study, it was observed that the treatment of STZ-induced diabetic mice with herbal KGE prevents hyperglycemia-induced dyslipidemia. Additionally, herbal KGE supplementation corrects the impaired glucose tolerance in diabetic mice. Herbal KGE supplementation improves altered biochemical parameters, such as liver and kidney function. Hematological analysis showed normalization of various altered blood indices in diabetic mice treated with herbal KGE. Furthermore, histopathological analysis of hepatocytes, cardiac, and renal tissue revealed regeneration and normalization upon herbal KGE supplementation following damage by STZ-induced hyperglycemia. Electron microscopy analysis of erythrocytes also revealed that herbal KGE supplementation had a protective effect on erythrocyte morphology. Inductively coupled plasma-optical emission spectroscopy (ICP-OES) analysis revealed the presence of various essential trace and major elements. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) phytochemical profiling analysis of herbal KGE revealed the presence of various compounds, such as flavonoids, polyphenols, alkaloids, coumaric acid, organic acid, and vitamins, which might be responsible for their anti-hyperglycemic and anti-hyperlipidemic activities with ethyl-p-methoxy-cinnamate (EPMC) as the major bioactive component. Therefore, from this study, it is observed that supplementation of diabetic mice with herbal KGE improved hyperglycemia-induced dyslipidemia and glucose tolerance while simultaneously provided tissue/cell protection against the damage caused by STZ-induced hyperglycemia.