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<p>This study aims to evaluate the protective role of <i>Phlogacanthus thyrsiflorus</i> (<i>P. thyrsiflorus</i>) on hyperglycemia induced oxidative stress and apoptosis in the hearts of diabetic mice. Acute toxicity testing and preliminary phytochemical screens were performed on methanolic flower extract (MFE) after it had been prepared. Thereafter, molecular docking was performed. The results identified active compounds which demonstrated strong binding affinity with the selected target proteins involved in oxidative stress under diabetic conditions. Moreover, the oxidative damage in the tissues of the Normal control mice (NCM), Diabetic control mice (DCM), Ascorbic acid-treated Diabetic mice (D + AA), and MFE-treated Diabetic mice (D + MFE) groups were assessed using lipid peroxidation and the protein carbonyl test. The diabetic mice treated with MFE showed a significant reduction in protein carbonyl levels and malondialdehyde (MDA). The effect of MFE on apoptosis was demonstrated by TUNEL enzyme where a few apoptotic cells were shown by the terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end labeling (TUNEL) assay. Therefore, in diabetic mice, the MFE of <i>P. thyrsiflorus</i> has cardiomyopathy benefits via controlling hyperglycemia-induced oxidative stress and apoptosis.</p>

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In silico analysis of Phlogacanthus thyrsiflorus Nees. and its protective effects against cardiomyopathic stress induced by alloxan in mice model

  • 期刊论文

  • 发表日期：

    2025年4月5日

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  • Jutishna Bora,
  • Sumira Malik,
  • Smita Lata,
  • Taranga Jyoti Baruah,
  • Sarvesh Rustagi,
  • Himanshu Ranjan,
  • Ravi K. Deshwal,
  • Seema Ramniwas,
  • Nayan Talukdar

摘要

This study aims to evaluate the protective role of Phlogacanthus thyrsiflorus (P. thyrsiflorus) on hyperglycemia induced oxidative stress and apoptosis in the hearts of diabetic mice. Acute toxicity testing and preliminary phytochemical screens were performed on methanolic flower extract (MFE) after it had been prepared. Thereafter, molecular docking was performed. The results identified active compounds which demonstrated strong binding affinity with the selected target proteins involved in oxidative stress under diabetic conditions. Moreover, the oxidative damage in the tissues of the Normal control mice (NCM), Diabetic control mice (DCM), Ascorbic acid-treated Diabetic mice (D + AA), and MFE-treated Diabetic mice (D + MFE) groups were assessed using lipid peroxidation and the protein carbonyl test. The diabetic mice treated with MFE showed a significant reduction in protein carbonyl levels and malondialdehyde (MDA). The effect of MFE on apoptosis was demonstrated by TUNEL enzyme where a few apoptotic cells were shown by the terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end labeling (TUNEL) assay. Therefore, in diabetic mice, the MFE of P. thyrsiflorus has cardiomyopathy benefits via controlling hyperglycemia-induced oxidative stress and apoptosis.