<p>Cyber-physical systems (CPSs) play a crucial role in modern transportation, particularly in transportation cyber-physical systems (TCPSs) for emergency supply logistics. By utilizing real-time data collection, analysis, and communication technologies, TCPS improves the efficiency, safety, and reliability of emergency supply transportation systems. However, existing research often overlooks the dynamic nature of the transportation environment and the complexities of joint emergency supply transportation amid uncertainty. The risk factors for both the physical and cyber layers are inadequately addressed. Consequently, assessing the risks associated with transporting emergency materials within CPS frameworks remains a significant challenge. This study proposes a risk assessment model based on TCPS to analyze the risks associated with transporting emergency supplies via various transportation modes. Initially, a comprehensive analysis of risk factors spanning both the cyber and physical layers within the TCPS is conducted. A risk assessment model is subsequently developed by considering transportation time costs, expenses, and delays. A risk area is then introduced to simulate the impact of recurrent emergency events on emergency supply transportation. Finally, we simulate emergency supply transportation scenarios to facilitate effective risk evaluation.</p>