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<p>From the defensive trait to therapeutic importance, Hymenopteran insects sting has been gaining attention for their health-beneficial importance. There is considerable evidence of the antimicrobial potency of insect venom and antimicrobial proteins (AMPs) in it. Thus, the antimicrobial potential of venomous extracts was evaluated from <i>Camponotus compressus</i> (CC), <i>Polistes wattii</i> (PW), and <i>Apis mellifera</i> (AM) against pathogenic bacteria <i>Escherichia coli</i> and <i>Pseudomonas aeruginosa</i>. Subsequently, global proteomic analysis led to the identification of 1286 across three insect species, of which 169 proteins were exclusively identified in the AM, 4 in CC, and 24 in the PW group, while 1126 were common to three groups. Of note, several AMPs were identified in AM (N = 13), CC (N = 9), and PW (N = 10). The results of our study provide a foundation for future studies to shape venom as an alternative to combat persistent bacterial infections.</p>

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Antimicrobial potential and global comparative proteomics of venom proteins from ants (Camponotus compressus), Wasp (Polistes wattii), and honey bee (Apis mellifera)

  • 期刊论文

  • 发表日期：

    2026年2月18日

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  • Ashish Kumar Lamiyan,
  • Vinod S. Bisht,
  • Kuldeep Giri,
  • Varsha Gupta,
  • Archana Chauhan,
  • Neelima R Kumar,
  • Kiran Ambatipudi

摘要

From the defensive trait to therapeutic importance, Hymenopteran insects sting has been gaining attention for their health-beneficial importance. There is considerable evidence of the antimicrobial potency of insect venom and antimicrobial proteins (AMPs) in it. Thus, the antimicrobial potential of venomous extracts was evaluated from Camponotus compressus (CC), Polistes wattii (PW), and Apis mellifera (AM) against pathogenic bacteria Escherichia coli and Pseudomonas aeruginosa. Subsequently, global proteomic analysis led to the identification of 1286 across three insect species, of which 169 proteins were exclusively identified in the AM, 4 in CC, and 24 in the PW group, while 1126 were common to three groups. Of note, several AMPs were identified in AM (N = 13), CC (N = 9), and PW (N = 10). The results of our study provide a foundation for future studies to shape venom as an alternative to combat persistent bacterial infections.