<p>In the context of low rubber price, coupled with labour restructuring, the Vietnamese rubber industry continues to face a shortage of skilled tappers. An experiment was established in April 2018 during the first year of tapping of clone RRIV 106 at Dong Phu Rubber Joint Stock Company in Binh Phuoc province. The objective of the experiment was to assess the impact of low-frequency tapping systems (d5 and d6) on latex yield, productivity, and physiological parameters. Compared to the control d4 ET2.5% 4/y, the dry rubber yield per tree per tapping as well as labour productivity in treatments d5 ET2.5% 6–8/y and d6 ET2.5% 8–10/y increased by 20–40%. The tapper requirements for low tapping frequency (d5 and d6) were 20% and 33% lower than those for d4, respectively. However, land productivity (kg ha⁻¹ year⁻¹) decreased by 1–4% and 6–7% when the tapping frequency was reduced from d4 to d5 and d6, respectively, due to a decrease in the number of tapping cuts per year. After seven years of consecutive tapping on the BO-1 tapping panel, the application of a low-frequency tapping system combined with using appropriate frequencies and dosages of stimulants did not adversely affect the biochemical parameters of rubber latex cells. The reduction of tapping frequency and intensification of hormonal stimulation had no significant impact on the girth increment of clone RRIV 106. Overall, under the conditions of Southeast Vietnam, a d5 tapping system with 6–8 stimulations per year appears to be the most suitable option for RRIV 106, offering a favourable balance between land productivity, labour saving, and the physiological balance of the tree.</p>