Scholarlink

<p>Oxidative stress, which is associated with excessive reactive oxygen species (ROS) production, is induced by air pollutants, such as fine particulate matter (PM<sub>2.5</sub>), and promotes inflammatory responses in the lungs, leading to the development and progression of pulmonary and cardiovascular diseases. <i>Citrullus lanatus</i> sp. 101117-1, commonly known as wild watermelon (WWM), is native to the Kalahari Desert in Southern Africa and is rich in citrulline and polyphenols with antioxidant properties. Thus, in the present study, we analyzed the effects of the juice of WWM (WWMJ) in a mouse model of air pollutant-induced lung injury and in an experimental cell system. Air pollutants increased the number of inflammatory cells (especially neutrophils), the expression of inflammatory cytokines and chemokines, and ROS production in the lungs of mice. However, oral administration of WWMJ markedly suppressed these responses. WWMJ also suppressed air pollutant-induced inflammatory responses and ROS production in RAW264 cells. Furthermore, analysis of cellular experimental systems showed that citrulline and pinoresinol, two components of WWMJ, may inhibit air pollutant-induced ROS production. These results suggest that WWMJ reduces acute lung injury induced by air pollutants, such as PM<sub>2.5</sub>, by exerting antioxidant effects in animal models. Although there are issues to be resolved, including long-term safety studies, the findings of this study are the first important results to establish WWMJ administration as a method for preventing adverse health effects resulting from exposure to environmental contaminants.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Animal experiment analyzing the preventive effects of wild watermelon on acute lung injury caused by urban aerosol particles in mice

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年8月27日

查看全文
  • Mikako Shimoda,
  • Ayaka Nakashima,
  • Sachie Shiota,
  • Ayano Hosaka,
  • Mai Watanabe,
  • Masahiro Kawahara,
  • Kosuke Yasuda,
  • Kengo Suzuki,
  • Ken-ichiro Tanaka

摘要

Oxidative stress, which is associated with excessive reactive oxygen species (ROS) production, is induced by air pollutants, such as fine particulate matter (PM2.5), and promotes inflammatory responses in the lungs, leading to the development and progression of pulmonary and cardiovascular diseases. Citrullus lanatus sp. 101117-1, commonly known as wild watermelon (WWM), is native to the Kalahari Desert in Southern Africa and is rich in citrulline and polyphenols with antioxidant properties. Thus, in the present study, we analyzed the effects of the juice of WWM (WWMJ) in a mouse model of air pollutant-induced lung injury and in an experimental cell system. Air pollutants increased the number of inflammatory cells (especially neutrophils), the expression of inflammatory cytokines and chemokines, and ROS production in the lungs of mice. However, oral administration of WWMJ markedly suppressed these responses. WWMJ also suppressed air pollutant-induced inflammatory responses and ROS production in RAW264 cells. Furthermore, analysis of cellular experimental systems showed that citrulline and pinoresinol, two components of WWMJ, may inhibit air pollutant-induced ROS production. These results suggest that WWMJ reduces acute lung injury induced by air pollutants, such as PM2.5, by exerting antioxidant effects in animal models. Although there are issues to be resolved, including long-term safety studies, the findings of this study are the first important results to establish WWMJ administration as a method for preventing adverse health effects resulting from exposure to environmental contaminants.