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<p>Cordycepin, a natural compound extracted from the fungus <i>Cordyceps militaris</i>, is a 3-deoxyadenosine and a key active ingredient in traditional Chinese medicine exhibiting promising anticancer properties. However, due to its poor bioavailability and short half-life, the usage of Cordycepin is limited clinically. To overcome these limitations, a liposome-based nanoformulation of cordycepin (CorLNP) is developed using thin-film hydration method. The physio-chemical properties of CorLNP revealed that, the particles are spherical in shape, the presence of functional groups is -OH and C = C groups, and these are playing major role in the formation CorLNP and maintaining the stability of the CorLNP. The entrapment efficiency of CorLNP 72% and drug loading capacity was 3.4%. The <i>in vitro</i> cytotoxicity and the apoptosis effect of the Cordycepin loaded liposome-based nano particles (CorLNP) and Cordycepin alone were assessed in human breast and cervical cancer cell lines. The CorLNP exhibited better cytotoxicity with greater fold-change both in MCF-7 and HeLa cell lines in a time dependant manner. These findings highlighted the incorporation of cordycepin into liposomal nanoparticles enhanced the bioavailability of cordycepin and significantly improved its anticancer efficacy.</p> Graphical abstract <p></p>

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Enhanced in vitro anticancer activity of liposome-encapsulated nanocordycepin in breast and cervical cancer cells

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月10日

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  • Sneha Sridhar,
  • Subba Rao V. Madhunapantula,
  • Prathibha Ranganathan,
  • Gopalakrishnan Velliyur Kanniappan,
  • Guru Kumar Dugganaboyana

摘要

Cordycepin, a natural compound extracted from the fungus Cordyceps militaris, is a 3-deoxyadenosine and a key active ingredient in traditional Chinese medicine exhibiting promising anticancer properties. However, due to its poor bioavailability and short half-life, the usage of Cordycepin is limited clinically. To overcome these limitations, a liposome-based nanoformulation of cordycepin (CorLNP) is developed using thin-film hydration method. The physio-chemical properties of CorLNP revealed that, the particles are spherical in shape, the presence of functional groups is -OH and C = C groups, and these are playing major role in the formation CorLNP and maintaining the stability of the CorLNP. The entrapment efficiency of CorLNP 72% and drug loading capacity was 3.4%. The in vitro cytotoxicity and the apoptosis effect of the Cordycepin loaded liposome-based nano particles (CorLNP) and Cordycepin alone were assessed in human breast and cervical cancer cell lines. The CorLNP exhibited better cytotoxicity with greater fold-change both in MCF-7 and HeLa cell lines in a time dependant manner. These findings highlighted the incorporation of cordycepin into liposomal nanoparticles enhanced the bioavailability of cordycepin and significantly improved its anticancer efficacy.

Graphical abstract