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<p>COVID-19 is a respiratory viral disease caused by acute respiratory syndrome coronavirus (SARS-CoV) that resulted in a significant pandemic. There is currently no effective antiviral medication to fight the deadly and extremely contagious COVID-19 virus. Some antiviral medicines acyclovir, amantadine, and zanamivir etc., have been utilized to treat various DNA/RNA viral infections like herpes simplex virus (HSV), varicella zoster virus (VZV), influenza virus, flu, etc. However, these antiviral drugs can lead to serious and potentially fatal complications like kidney disorders, liver and bile duct cancers, cirrhosis, heart failure, peripheral nerve disorders, irritability, depression, migraines, psychosis, diarrhoea, and vomiting. So, there is a need to find out natural and effective antiviral drugs against emerging viruses such as coronavirus variants; hepatitis C, hepatitis B, Ebola, influenza, polio, and HIV without any side effects. The aim of the present review is to explore natural plant-based therapeutics mainly from <i>Glycyrrhiza glabra, Azadirachta indica, Aloe vera, Curcuma longa, Ocimum basilinum, Ocimum sanctum, Tinospora cordifolia</i> etc., to treat the viral infection-related diseases such as COVID-19, influenza, hepatitis B, hepatitis C, HIV, and herpes simplex virus (HPV). The review paper also highlights the modes of action of phytocompounds to determine the therapeutic value of natural plant extracts against viral diseases. The findings of this review paper suggest that these plants have a high amount of bioactive components, which potentially obstruct viral entry into the host cell, prevent viral multiplication, and boost immunity, which can be applied in creating new antiviral medications for treating viral infections.</p>

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A systematic review on nutraceuticals as a potential source of therapeutics against COVID-19 and other emerging viral diseases

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月30日

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  • Pankaj Singh,
  • Fareha Rayeen,
  • Roli Singh,
  • Manikant Tripathi,
  • Pradeep Kumar Singh,
  • Saba Ubaid,
  • Neelam Pathak

摘要

COVID-19 is a respiratory viral disease caused by acute respiratory syndrome coronavirus (SARS-CoV) that resulted in a significant pandemic. There is currently no effective antiviral medication to fight the deadly and extremely contagious COVID-19 virus. Some antiviral medicines acyclovir, amantadine, and zanamivir etc., have been utilized to treat various DNA/RNA viral infections like herpes simplex virus (HSV), varicella zoster virus (VZV), influenza virus, flu, etc. However, these antiviral drugs can lead to serious and potentially fatal complications like kidney disorders, liver and bile duct cancers, cirrhosis, heart failure, peripheral nerve disorders, irritability, depression, migraines, psychosis, diarrhoea, and vomiting. So, there is a need to find out natural and effective antiviral drugs against emerging viruses such as coronavirus variants; hepatitis C, hepatitis B, Ebola, influenza, polio, and HIV without any side effects. The aim of the present review is to explore natural plant-based therapeutics mainly from Glycyrrhiza glabra, Azadirachta indica, Aloe vera, Curcuma longa, Ocimum basilinum, Ocimum sanctum, Tinospora cordifolia etc., to treat the viral infection-related diseases such as COVID-19, influenza, hepatitis B, hepatitis C, HIV, and herpes simplex virus (HPV). The review paper also highlights the modes of action of phytocompounds to determine the therapeutic value of natural plant extracts against viral diseases. The findings of this review paper suggest that these plants have a high amount of bioactive components, which potentially obstruct viral entry into the host cell, prevent viral multiplication, and boost immunity, which can be applied in creating new antiviral medications for treating viral infections.