Abstract <p>Quadrisociation, a novel framework for creative synthesis, integrates four distinct concepts to foster innovation across diverse domains. This paper explores its principles, processes, and practical applications, focusing on its alignment with societal challenges and the transformative role of generative artificial intelligence (AI). By leveraging the computational power of large language models (LLMs), quadrisociation enables the identification and synthesis of multidimensional connections, offering a structured yet flexible approach to problem-solving. Healthcare, sustainability, and product design examples demonstrate how this framework addresses complex, interdisciplinary challenges. Immersive telehealth environments, combining augmented reality, virtual reality, telemedicine, and sustainable design, exemplify quadrisociation's potential to revolutionize healthcare delivery. Similarly, the conceptual design of a self-cleaning smart water bottle integrates solar energy, nanotechnology, IoT connectivity, and behavioral psychology, highlighting its capability to promote sustainability and health. These case studies illustrate quadrisociation's ability to enhance societal well-being by fostering collaboration, creativity, and technological advancement. This paper positions quadrisociation as a critical tool for addressing interconnected societal issues, advocating for its adoption across academia, industry, and policy. By emphasizing the role of generative AI in enhancing creative processes, this work underscores the need for interdisciplinary innovation in shaping a sustainable, equitable, and technologically advanced future.</p>