<p>The paper develops and investigates various options for separating the first and second stages of a promising launch vehicle without using pyrotechnic elements (such as the “Clamp Band” type, “petal” and “ball” types). A review and analysis of the applicability of pyrotechnic elements as part of separation devices of existing and promising launch vehicles was carried out, as a result, it was revealed that their use is difficult for technological reasons related to the need for specialized devices and equipment for accurate control of the detonation process and the likelihood of a large number of fragments and shock loads during operation, which negatively affects the provision of specified structural and operational characteristics of launch vehicles. The basic requirements for ensuring the rational operation of the proposed separation devices, taking into account the possibility of their multiple use, are considered. Experimental and mathematical modeling of relative motion of the stages separating according to the “cold” scheme under the influence of static and dynamic loads has been carried out, and rational technical solutions and design and technological approaches for the proposed separation devices have been selected. The results of the research on assessment of the stress–strain state of structural elements of the proposed separation devices without using pyrotechnic elements in various configurations, as well as their novelty, are presented.</p>