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Background <p>It has been suggested that periodontitis is associated with hypertension. The main goal of this systematic review and meta-analysis is to assess the current evidence regarding this association.</p> Methods <p>The protocol of this study was registered in PROSPERO (CRD420251152649) and written under the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. For the risk of bias assessment in the included studies, the Newcastle–Ottawa Scale (NOS) was used. A random-effects model was used for all analyses to account for variability across included studies.</p> Results <p>Thirty-eight studies, including 992,547 patients, met the inclusion criteria. The analysis showed that having periodontitis was associated with higher odds of diagnosis with hypertension (OR: 1.38, 95% CI 1.26–1.51, <i>p</i> &lt; 0.01). Severe periodontitis was associated with higher odds of hypertension (OR: 1.41, 95% CI 1.20–1.65, <i>p</i> &lt; 0.01). Moderate periodontitis was linked to hypertension, resulting in a pooled OR of 1.13 (95% CI 0.97–1.32); however, this association was not statistically significant (<i>p</i> = 0.11). Presence of periodontitis was shown to be associated with higher odds of increased systolic blood pressure (OR: 1.37, 95% CI 1.16–1.62, <i>p</i> &lt; 0.01). Periodontitis was also linked to elevated diastolic blood pressure (OR: 1.59, 95% CI 1.03–2.45, <i>p</i> = 0.04).</p> Conclusion <p>Severe periodontitis is associated with a higher likelihood of hypertension. Future research is warranted to focus on whether timely treatment of periodontitis affects long-term cardiovascular events.</p>

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Does Periodontitis Increase the Risk of Hypertension? A Systematic Review and Meta-Analysis

  • 期刊论文

  • 发表日期：

    2026年7月18日

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  • Parsa Taghavi,
  • Ava Farzaneh,
  • Baharak Sabzevari,
  • Armin Karamian

摘要

Background

It has been suggested that periodontitis is associated with hypertension. The main goal of this systematic review and meta-analysis is to assess the current evidence regarding this association.

Methods

The protocol of this study was registered in PROSPERO (CRD420251152649) and written under the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. For the risk of bias assessment in the included studies, the Newcastle–Ottawa Scale (NOS) was used. A random-effects model was used for all analyses to account for variability across included studies.

Results

Thirty-eight studies, including 992,547 patients, met the inclusion criteria. The analysis showed that having periodontitis was associated with higher odds of diagnosis with hypertension (OR: 1.38, 95% CI 1.26–1.51, p < 0.01). Severe periodontitis was associated with higher odds of hypertension (OR: 1.41, 95% CI 1.20–1.65, p < 0.01). Moderate periodontitis was linked to hypertension, resulting in a pooled OR of 1.13 (95% CI 0.97–1.32); however, this association was not statistically significant (p = 0.11). Presence of periodontitis was shown to be associated with higher odds of increased systolic blood pressure (OR: 1.37, 95% CI 1.16–1.62, p < 0.01). Periodontitis was also linked to elevated diastolic blood pressure (OR: 1.59, 95% CI 1.03–2.45, p = 0.04).

Conclusion

Severe periodontitis is associated with a higher likelihood of hypertension. Future research is warranted to focus on whether timely treatment of periodontitis affects long-term cardiovascular events.