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Objective <p>This study aimed to evaluate serum omentin levels and its association with insulin, hemoglobin A1c, glucose, and lipid profile in Palestinian women with type 2 diabetes mellitus.</p> Methods <p>This observational case–control study recruited 200 participants aged 30–60 years and divided them into control and case groups. Cases consist of 150 type 2 diabetic females categorized according to their BMI as the <i>normal weight group</i> (BMI &lt; 25&#xa0;kg/m<sup>2</sup>), the <i>overweight group</i> (BMI 25–29.9&#xa0;kg/m<sup>2</sup>), and the <i>obese group</i> (BMI ≥ 30&#xa0;kg/m<sup>2</sup>) with a fasting glucose level &gt; 150&#xa0;mg/dl. Diabetic females received a combination of metformin 500&#xa0;mg and glimepiride 2&#xa0;mg once daily with breakfast all over the study period. In addition to 50 apparently healthy females with normal weight (BMI &lt; 25&#xa0;kg/m<sup>2</sup>) and fasting glucose level &lt; 90.0&#xa0;mg/dl as a <i>control group</i>. Sociodemographic data, clinical history, anthropometric measurements, blood pressure, and pulse rate were collected from all subjects. Serum omentin-1, insulin, hemoglobin A1c, glucose, and lipid profile were measured and statistically analyzed.</p> Results <p>Compared with controls, diabetic participants showed significantly increased body weight, waist circumference, BMI, and both systolic and diastolic blood pressure (<i>P</i> &lt; 0.05). Serum omentin level was significantly increased in overweight diabetic and obese diabetic patients compared to control (<i>P</i> &lt; 0.05). HbA1c, fasting glucose, and HOMA-IR levels were significantly higher across all diabetic groups (<i>P</i> &lt; 0.001). All diabetic patients had increased cholesterol and triglyceride levels with decreased HDL values, indicating dyslipidemia. The person’s correlation analysis showed a strong positive correlation between BMI and body weight and waist circumference in all groups (<i>P</i> ≤ 0.01).</p> Conclusions <p>The results revealed that serum omentin-1 is associated with HbA1c, glucose, lipid profile, and metabolic disturbances in T2DM patients. Further investigations for a potential biomarker were needed.</p>

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Association of Serum Omentin-1 with Insulin, Hemoglobin A1c, Glucose, and Lipid Profile in Palestinian Women with Type 2 Diabetes Mellitus

  • 期刊论文

  • 发表日期：

    2026年7月27日

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  • Saleh N. Mwafy,
  • Maysaa F. Abu-Namous

摘要

Objective

This study aimed to evaluate serum omentin levels and its association with insulin, hemoglobin A1c, glucose, and lipid profile in Palestinian women with type 2 diabetes mellitus.

Methods

This observational case–control study recruited 200 participants aged 30–60 years and divided them into control and case groups. Cases consist of 150 type 2 diabetic females categorized according to their BMI as the normal weight group (BMI < 25 kg/m2), the overweight group (BMI 25–29.9 kg/m2), and the obese group (BMI ≥ 30 kg/m2) with a fasting glucose level > 150 mg/dl. Diabetic females received a combination of metformin 500 mg and glimepiride 2 mg once daily with breakfast all over the study period. In addition to 50 apparently healthy females with normal weight (BMI < 25 kg/m2) and fasting glucose level < 90.0 mg/dl as a control group. Sociodemographic data, clinical history, anthropometric measurements, blood pressure, and pulse rate were collected from all subjects. Serum omentin-1, insulin, hemoglobin A1c, glucose, and lipid profile were measured and statistically analyzed.

Results

Compared with controls, diabetic participants showed significantly increased body weight, waist circumference, BMI, and both systolic and diastolic blood pressure (P < 0.05). Serum omentin level was significantly increased in overweight diabetic and obese diabetic patients compared to control (P < 0.05). HbA1c, fasting glucose, and HOMA-IR levels were significantly higher across all diabetic groups (P < 0.001). All diabetic patients had increased cholesterol and triglyceride levels with decreased HDL values, indicating dyslipidemia. The person’s correlation analysis showed a strong positive correlation between BMI and body weight and waist circumference in all groups (P ≤ 0.01).

Conclusions

The results revealed that serum omentin-1 is associated with HbA1c, glucose, lipid profile, and metabolic disturbances in T2DM patients. Further investigations for a potential biomarker were needed.