Scholarlink

Introduction <p>Primary mediastinal tumors are rare in children and may present with variable, nonspecific clinical manifestations depending on tumor location, histology, and compression of adjacent structures. This study aimed to describe the clinicopathological characteristics, anatomical distribution, treatment patterns, and outcome status of primary mediastinal tumors in children admitted to Shahid Sadoughi Hospital, Yazd, Iran, from 2011 to 2021.</p> Materials and Methods <p>This single-center retrospective descriptive study included all eligible patients younger than 18 years with histologically confirmed primary mediastinal tumors admitted to Shahid Sadoughi Hospital, Yazd, Iran, between 2011 and 2021. Data on demographic characteristics, presenting symptoms, tumor location, histopathological diagnosis, malignancy status, treatment modalities, and outcome status were extracted using a predefined checklist. Data were analyzed using IBM SPSS Statistics, Version 22.0. Because of the small sample size and limited number of deaths, outcomes were summarized descriptively rather than analyzed as independent prognostic factors.</p> Results <p>Of the total 17 children in the study, 12 (70.6%) were girls and 5 (29.4%) were boys. There were 5 mortality cases (29.4%). Also, of the 17 masses examined, 9 (53%) were classified as benign and 8 (47%) were malignant. Ganglioneuroma was estimated to be the most frequent tumor with a 29.4% frequency. At the last available follow-up, 12 patients were alive and 5 had died. All deaths occurred among patients with malignant tumors. Because of the small cohort size and limited number of events, survival outcomes were summarized descriptively rather than analyzed as independent prognostic factors.</p> Discussion and Conclusion <p>The findings suggest that anatomical location may provide useful diagnostic clues regarding tumor histology, particularly because neurogenic tumors were mainly observed in the posterior mediastinum. However, because of the small sample size, the findings should be interpreted as descriptive and hypothesis-generating.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Clinicopathological Characteristics of Primary Mediastinal Tumors in Children: A Single-Center Retrospective Descriptive Study from Yazd, Iran

  • 期刊论文

  • 发表日期：

    2026年7月1日

查看全文
  • Mahlagha Zahedi,
  • Hamed Afkhami,
  • Zahra-Sadat Razavi,
  • Mahdieh Toufanian,
  • Sahar Abassinia

摘要

Introduction

Primary mediastinal tumors are rare in children and may present with variable, nonspecific clinical manifestations depending on tumor location, histology, and compression of adjacent structures. This study aimed to describe the clinicopathological characteristics, anatomical distribution, treatment patterns, and outcome status of primary mediastinal tumors in children admitted to Shahid Sadoughi Hospital, Yazd, Iran, from 2011 to 2021.

Materials and Methods

This single-center retrospective descriptive study included all eligible patients younger than 18 years with histologically confirmed primary mediastinal tumors admitted to Shahid Sadoughi Hospital, Yazd, Iran, between 2011 and 2021. Data on demographic characteristics, presenting symptoms, tumor location, histopathological diagnosis, malignancy status, treatment modalities, and outcome status were extracted using a predefined checklist. Data were analyzed using IBM SPSS Statistics, Version 22.0. Because of the small sample size and limited number of deaths, outcomes were summarized descriptively rather than analyzed as independent prognostic factors.

Results

Of the total 17 children in the study, 12 (70.6%) were girls and 5 (29.4%) were boys. There were 5 mortality cases (29.4%). Also, of the 17 masses examined, 9 (53%) were classified as benign and 8 (47%) were malignant. Ganglioneuroma was estimated to be the most frequent tumor with a 29.4% frequency. At the last available follow-up, 12 patients were alive and 5 had died. All deaths occurred among patients with malignant tumors. Because of the small cohort size and limited number of events, survival outcomes were summarized descriptively rather than analyzed as independent prognostic factors.

Discussion and Conclusion

The findings suggest that anatomical location may provide useful diagnostic clues regarding tumor histology, particularly because neurogenic tumors were mainly observed in the posterior mediastinum. However, because of the small sample size, the findings should be interpreted as descriptive and hypothesis-generating.