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Purpose <p>Chronic kidney disease (CKD) is a significant contributor to stroke-related mortality. Stroke risk increases in a stepwise manner as kidney function declines. However, trends of death rate due to stroke among individuals over 45 years of age with CKD have not been well described. The aim of this study is to evaluate stroke-related mortality among adults aged ≥ 45 with CKD in the United States.</p> Methods <p>Utilizing the CDC WONDER database, death certificates were examined from 1999 to 2023 for stroke-related mortality in adults with CKD aged ≥ 45 years. Age-adjusted mortality rates (AAMR) per 100,000 individuals, annual percentage changes (APC), average annual percent changes (AAPC), and 95% confidence intervals were calculated.</p> Results <p>From 1999 to 2023, 43,608 deaths were reported because of stroke among patients with CKD. The AAMR decreased from 1.96 per 100,000 in 1999 to 1.36 per 100,000 in 2023, with an AAPC of -1.14 (95% CI: -4.10 to 1.92, <i>p</i> = 0.462498). Persistently, AAMR was higher in males than in females (AAMR: 1.69 vs. 1.27). Across racial groups, NH Black or African American cohorts demonstrated the highest AAMR (3.66). For age groups, individuals of age ≥ 85 years showed consistently higher crude mortality rates (10.19). West and non-metropolitan areas showed the highest AAMRs, pointing towards the existence of regional disparities.</p> Conclusion <p>Stroke-related mortality in individuals with CKD has shown a net decline. However, disparities are fluctuating with an increasing trend since 2015, across various demographic and geographic groups. These findings reinforce the urgent need for specific equity-focused prevention measures and promotion of health education.</p>

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Trends and Disparities in Age–Adjusted Stroke Mortality Among Adults (≥ 45 Years) with Chronic Kidney Disease in the United States, 1999 to 2023: a CDC WONDER Database Analysis

  • 期刊论文

  • 发表日期：

    2026年5月14日

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  • Muhammad Bilal Aamir,
  • Tehreem Tariq,
  • Saad Shakil,
  • Anushah Faheem Ilyas,
  • Alishba Inshal Qasim,
  • Dania Nadeem,
  • Malik Arsalan Hanif,
  • Vania Saleem,
  • Hassaan Umar Khan,
  • Muhammad Aamir Saghir,
  • Aqdas Hakeem

摘要

Purpose

Chronic kidney disease (CKD) is a significant contributor to stroke-related mortality. Stroke risk increases in a stepwise manner as kidney function declines. However, trends of death rate due to stroke among individuals over 45 years of age with CKD have not been well described. The aim of this study is to evaluate stroke-related mortality among adults aged ≥ 45 with CKD in the United States.

Methods

Utilizing the CDC WONDER database, death certificates were examined from 1999 to 2023 for stroke-related mortality in adults with CKD aged ≥ 45 years. Age-adjusted mortality rates (AAMR) per 100,000 individuals, annual percentage changes (APC), average annual percent changes (AAPC), and 95% confidence intervals were calculated.

Results

From 1999 to 2023, 43,608 deaths were reported because of stroke among patients with CKD. The AAMR decreased from 1.96 per 100,000 in 1999 to 1.36 per 100,000 in 2023, with an AAPC of -1.14 (95% CI: -4.10 to 1.92, p = 0.462498). Persistently, AAMR was higher in males than in females (AAMR: 1.69 vs. 1.27). Across racial groups, NH Black or African American cohorts demonstrated the highest AAMR (3.66). For age groups, individuals of age ≥ 85 years showed consistently higher crude mortality rates (10.19). West and non-metropolitan areas showed the highest AAMRs, pointing towards the existence of regional disparities.

Conclusion

Stroke-related mortality in individuals with CKD has shown a net decline. However, disparities are fluctuating with an increasing trend since 2015, across various demographic and geographic groups. These findings reinforce the urgent need for specific equity-focused prevention measures and promotion of health education.