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Background/Objective <p>Preeclampsia (PE) is a multisystem disorder characterized by hypertension and proteinuria after 20 weeks of gestation. Recent evidence suggests that hematological markers such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) may serve as cost-effective indicators of disease severity. This study aimed to evaluate the diagnostic and the association of NLR, PLR, and MPV with the severity of PE.</p> Methods <p>A case-control study was conducted on 244 pregnant women, 122 normotensive and 122 preeclamptic, attending a tertiary care hospital. The PE group was further divided into mild and severe subgroups. Complete blood count-derived indices (NLR, PLR, and MPV) were analyzed using SPSS version 25. Receiver operating characteristic (ROC) analysis was employed to determine cutoff values, sensitivity, and specificity.</p> Results <p>Absolute and percentage neutrophil counts, MPV, and NLR were significantly elevated in preeclamptic women compared to controls (<i>p</i> &lt; 0.05). Neutrophil indices, MPV, and NLR increased with severity, whereas PLR did not differ significantly across severity groups. ROC analysis for discrimination of PE from non-PE identified optimal cutoff values of 2.62 for NLR and 8.55 fL for MPV. However, discriminatory performance was modest for both markers, and they are best interpreted as supportive indicators associated with PE rather than standalone diagnostic tools.</p> Conclusion <p>NLR, MPV, and neutrophil counts are reliable supportive markers associated with PE and its severity. As inexpensive and readily available indices, they hold potential for early risk stratification, especially in resource-limited settings, when used alongside established clinical criteria. Further large-scale, multicentric studies are recommended to standardize their clinical application.</p>

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Hematological Indices and Their Association with Mild and Severe Pre-eclampsia: A Case Control Study

  • 期刊论文

  • 发表日期：

    2026年4月13日

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  • Mueez Haider,
  • Arifa Maryum,
  • Shahzaib Maqbool,
  • Muhammad Sarfraz Khan,
  • Abdur Rehman,
  • Arslan Kareem

摘要

Background/Objective

Preeclampsia (PE) is a multisystem disorder characterized by hypertension and proteinuria after 20 weeks of gestation. Recent evidence suggests that hematological markers such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) may serve as cost-effective indicators of disease severity. This study aimed to evaluate the diagnostic and the association of NLR, PLR, and MPV with the severity of PE.

Methods

A case-control study was conducted on 244 pregnant women, 122 normotensive and 122 preeclamptic, attending a tertiary care hospital. The PE group was further divided into mild and severe subgroups. Complete blood count-derived indices (NLR, PLR, and MPV) were analyzed using SPSS version 25. Receiver operating characteristic (ROC) analysis was employed to determine cutoff values, sensitivity, and specificity.

Results

Absolute and percentage neutrophil counts, MPV, and NLR were significantly elevated in preeclamptic women compared to controls (p < 0.05). Neutrophil indices, MPV, and NLR increased with severity, whereas PLR did not differ significantly across severity groups. ROC analysis for discrimination of PE from non-PE identified optimal cutoff values of 2.62 for NLR and 8.55 fL for MPV. However, discriminatory performance was modest for both markers, and they are best interpreted as supportive indicators associated with PE rather than standalone diagnostic tools.

Conclusion

NLR, MPV, and neutrophil counts are reliable supportive markers associated with PE and its severity. As inexpensive and readily available indices, they hold potential for early risk stratification, especially in resource-limited settings, when used alongside established clinical criteria. Further large-scale, multicentric studies are recommended to standardize their clinical application.