Scholarlink

<p>Acute coronary syndrome (ACS) remains a major contributor to global cardiovascular morbidity and mortality. Prompt and accurate diagnosis is vital, particularly during the early presentation when conventional biomarkers such as troponin I may be falsely negative. Immature platelet fraction (IPF), a parameter reflecting thrombopoietic activity and platelet turnover, has emerged as a potentially valuable marker in ACS. This narrative review summarizes and evaluates existing literature on the potential clinical utility of IPF in ACS, highlights its advantages and limitations, and outlines gaps for future research. While current evidence supports elevated IPF levels in ACS and its potential to predict major adverse cardiac events (MACE), larger multicentric studies with standardized methodologies are warranted to validate its clinical integration.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Immature Platelet Fraction in Acute Coronary Syndrome: A Narrative Review of Current Evidence and Potential Clinical Implications

  • 期刊论文

  • 发表日期：

    2026年4月18日

查看全文
  • Anusha Lakmali,
  • Chandima Kulathilake

摘要

Acute coronary syndrome (ACS) remains a major contributor to global cardiovascular morbidity and mortality. Prompt and accurate diagnosis is vital, particularly during the early presentation when conventional biomarkers such as troponin I may be falsely negative. Immature platelet fraction (IPF), a parameter reflecting thrombopoietic activity and platelet turnover, has emerged as a potentially valuable marker in ACS. This narrative review summarizes and evaluates existing literature on the potential clinical utility of IPF in ACS, highlights its advantages and limitations, and outlines gaps for future research. While current evidence supports elevated IPF levels in ACS and its potential to predict major adverse cardiac events (MACE), larger multicentric studies with standardized methodologies are warranted to validate its clinical integration.