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Background <p>Previous reports have suggested concurrence of cervical dystonia (CD) and chronic migraine (CM); however, the extent of the burden is unclear. This analysis estimated the prevalence of comorbid CD and CM (CD + CM) and described patient characteristics and health care costs among real-world patients with CD + CM.</p> Methods <p>This retrospective cohort study used administrative claims data from the Merative MarketScan (January 1, 2017–December 31, 2021) and Optum<sup>®</sup> Market Clarity databases (January 1, 2017–September 30, 2021). Adults with CD and/or CM were identified using ICD-10-CM diagnosis codes. Outcomes were summarized descriptively and included prevalence of CD, CM, and CD + CM; relative risk of comorbid CD + CM; patient characteristics stratified by cohort and botulinum neurotoxin (BoNT) exposure status; and health care costs for CD + CM.</p> Results <p>In 2017–2021, numbers of patients identified as above annually ranged from 10.5&#xa0;million to 16.3&#xa0;million. The relative risk of CM among patients with CD, and of CD among patients with CM, was 31.8 and 39.5, respectively. Among patients with CD, the overall prevalence of CD + CM from 2017 to 2021 was 12.6%. The overall prevalence of neck pain was 63.6% during the study period. Mean annual all-cause health care costs were significantly greater for patients with CD + CM ($32,218) versus those with CD alone ($20,633; <i>P</i> &lt; 0.001), CM alone ($19,389; <i>P</i> &lt; 0.001), and neither ($6449; <i>P</i> &lt; 0.0001) across the study period.</p> Conclusions <p>CD and CM are frequently comorbid and constitute a substantial burden. Clinicians should consider a diagnostic approach incorporating evaluation for both conditions to facilitate timely access to appropriate care.</p>

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Diagnosis, Demographic and Clinical Characteristics, and Real-World Health Care Costs Among Patients with Comorbid Cervical Dystonia and Chronic Migraine

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月29日

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  • Harini Sarva,
  • Marjan Sadeghi,
  • Susan Broner,
  • Kim Becker Ifantides,
  • Ramon Rodriguez,
  • Christopher Rhyne,
  • Ahunna Ukah,
  • Brett Pinsky,
  • Eric Hillson,
  • Grace Forde

摘要

Background

Previous reports have suggested concurrence of cervical dystonia (CD) and chronic migraine (CM); however, the extent of the burden is unclear. This analysis estimated the prevalence of comorbid CD and CM (CD + CM) and described patient characteristics and health care costs among real-world patients with CD + CM.

Methods

This retrospective cohort study used administrative claims data from the Merative MarketScan (January 1, 2017–December 31, 2021) and Optum® Market Clarity databases (January 1, 2017–September 30, 2021). Adults with CD and/or CM were identified using ICD-10-CM diagnosis codes. Outcomes were summarized descriptively and included prevalence of CD, CM, and CD + CM; relative risk of comorbid CD + CM; patient characteristics stratified by cohort and botulinum neurotoxin (BoNT) exposure status; and health care costs for CD + CM.

Results

In 2017–2021, numbers of patients identified as above annually ranged from 10.5 million to 16.3 million. The relative risk of CM among patients with CD, and of CD among patients with CM, was 31.8 and 39.5, respectively. Among patients with CD, the overall prevalence of CD + CM from 2017 to 2021 was 12.6%. The overall prevalence of neck pain was 63.6% during the study period. Mean annual all-cause health care costs were significantly greater for patients with CD + CM ($32,218) versus those with CD alone ($20,633; P < 0.001), CM alone ($19,389; P < 0.001), and neither ($6449; P < 0.0001) across the study period.

Conclusions

CD and CM are frequently comorbid and constitute a substantial burden. Clinicians should consider a diagnostic approach incorporating evaluation for both conditions to facilitate timely access to appropriate care.