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Introduction <p>In this report, we describe a case of lipomatous tumor with an uncharacteristic degree of cellular atypia, a feature that raised concern for malignant adipocytic neoplasms.</p> Case Presentation <p>The patient presented with a lump on his neck that was biopsied and found to be on the upper limit of benign on histology but was later determined to be pleomorphic lipoma through detailed analysis. This case highlights the importance of integrating histologic, immunohistochemical, and molecular findings to avoid misdiagnosis and overtreatment.</p> Conclusions <p>We review common clinical presentations of similar appearing lipomatous tumors as well as their typical course and management. We provide representative histology, immunohistochemistry, and molecular analysis with discussion of lipomatous tumors which serves to add to the recognition of this entity and the differential diagnosis in the complex area of adipocytic neoplasms.</p>

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Case Report: A Well-characterized Pleomorphic Lipoma and Histological Mimics

  • 期刊论文

  • 发表日期：

    2026年4月1日

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  • John S. Pujals,
  • Bruce D. Leckey Jr,
  • Gabrielle Kartzmark,
  • Ryan F. Bloomquist

摘要

Introduction

In this report, we describe a case of lipomatous tumor with an uncharacteristic degree of cellular atypia, a feature that raised concern for malignant adipocytic neoplasms.

Case Presentation

The patient presented with a lump on his neck that was biopsied and found to be on the upper limit of benign on histology but was later determined to be pleomorphic lipoma through detailed analysis. This case highlights the importance of integrating histologic, immunohistochemical, and molecular findings to avoid misdiagnosis and overtreatment.

Conclusions

We review common clinical presentations of similar appearing lipomatous tumors as well as their typical course and management. We provide representative histology, immunohistochemistry, and molecular analysis with discussion of lipomatous tumors which serves to add to the recognition of this entity and the differential diagnosis in the complex area of adipocytic neoplasms.