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<p>Nearly 90% of cases and fatalities worldwide occur in low- and middle-income countries (LMICs), where cervical cancer continues to be a significant public health concern. Even though there is strong evidence that high-risk human papillomavirus (HPV) infection is linked to cervical cancer and that effective vaccination and screening methods are available, many LMICs continue to face implementation challenges due to a lack of funding, inadequate health infrastructure, a lack of workers, and societal barriers. These difficulties have led to inadequate coverage of the HPV vaccine and cervical cancer screening, as well as disjointed prevention initiatives. Promising prospects for enhancing cervical cancer prevention in settings with limited resources are presented by recent data showing the immunogenicity and long-term protective efficacy of single-dose HPV vaccination, as well as the high diagnostic accuracy and acceptability of HPV DNA self-sampling. Hence, we conducted a narrative, evidence-informed policy commentary to suggest an integrated approach that combines HPV DNA self-sampling for adult women with national or subnational single-dose HPV vaccine for girls aged 9–14. Key operational elements that are specific to LMIC contexts are outlined in the proposed plan, including micro-planning, supply chain strengthening, community participation, laboratory expansion, and referral channels. Adopting these straightforward, scalable strategies could significantly advance LMICs toward meeting the WHO 90-70-90 targets and lowering the global disparities in cervical cancer burden, even while significant financial, logistical, and educational obstacles still exist.</p>

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HPV One-Shot Vaccination and Self-Sampling: A Policy Commentary for the Eradication of Cervical Cancer in Low-and-Middle-Income Countries

  • 期刊论文

  • 发表日期：

    2026年4月23日

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  • Thien Dang Huu,
  • Manuela Bombana,
  • Abdelrahman M. Makram,
  • Shurouq Ashraf Tabash,
  • Phan Vinh Nghi,
  • Nguyen Tien Huy

摘要

Nearly 90% of cases and fatalities worldwide occur in low- and middle-income countries (LMICs), where cervical cancer continues to be a significant public health concern. Even though there is strong evidence that high-risk human papillomavirus (HPV) infection is linked to cervical cancer and that effective vaccination and screening methods are available, many LMICs continue to face implementation challenges due to a lack of funding, inadequate health infrastructure, a lack of workers, and societal barriers. These difficulties have led to inadequate coverage of the HPV vaccine and cervical cancer screening, as well as disjointed prevention initiatives. Promising prospects for enhancing cervical cancer prevention in settings with limited resources are presented by recent data showing the immunogenicity and long-term protective efficacy of single-dose HPV vaccination, as well as the high diagnostic accuracy and acceptability of HPV DNA self-sampling. Hence, we conducted a narrative, evidence-informed policy commentary to suggest an integrated approach that combines HPV DNA self-sampling for adult women with national or subnational single-dose HPV vaccine for girls aged 9–14. Key operational elements that are specific to LMIC contexts are outlined in the proposed plan, including micro-planning, supply chain strengthening, community participation, laboratory expansion, and referral channels. Adopting these straightforward, scalable strategies could significantly advance LMICs toward meeting the WHO 90-70-90 targets and lowering the global disparities in cervical cancer burden, even while significant financial, logistical, and educational obstacles still exist.