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Background <p>Renal cell carcinoma (RCC) remains the most prevalent malignancy of the adult kidney, typically diagnosed between the sixth and seventh decades. While calcification is detected histologically or radiologically in 8–31% of RCCs, true osseous metaplasia—bone formation within the tumor stroma—is a rarity. To the best of our knowledge, fewer than 30 cases have been reported until 2020.</p> Case Report <p>Herein, we present the case of a 42-year-old man with a hard, left-sided abdominal mass, who underwent nephrectomy. Contrast-enhanced computer tomography scan revealed a sharply delineated, heterogeneous mass in the lower pole of the left kidney.</p> Results <p>The histopathology was reported as clear cell RCC with prominent osseous metaplasia. This report presents an extensive histopathological analysis and an evidence-based discussion of the etiopathogenesis and implications, accompanied by a comprehensive literature review of this rare finding.</p> Conclusions <p>Osseous metaplasia in RCC is an uncommon but histologically noteworthy finding with possible implications for the biology and chronological development of the tumor.</p>

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Clear Cell Renal Cell Carcinoma With Extensive Osseous Metaplasia in a Young Adult: Case Report and Literature Review

  • 期刊论文

  • 发表日期：

    2026年4月1日

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  • Saumya Shivkumar Saxena,
  • Rakesh Kumar Gupta,
  • Amit R. Sharma

摘要

Background

Renal cell carcinoma (RCC) remains the most prevalent malignancy of the adult kidney, typically diagnosed between the sixth and seventh decades. While calcification is detected histologically or radiologically in 8–31% of RCCs, true osseous metaplasia—bone formation within the tumor stroma—is a rarity. To the best of our knowledge, fewer than 30 cases have been reported until 2020.

Case Report

Herein, we present the case of a 42-year-old man with a hard, left-sided abdominal mass, who underwent nephrectomy. Contrast-enhanced computer tomography scan revealed a sharply delineated, heterogeneous mass in the lower pole of the left kidney.

Results

The histopathology was reported as clear cell RCC with prominent osseous metaplasia. This report presents an extensive histopathological analysis and an evidence-based discussion of the etiopathogenesis and implications, accompanied by a comprehensive literature review of this rare finding.

Conclusions

Osseous metaplasia in RCC is an uncommon but histologically noteworthy finding with possible implications for the biology and chronological development of the tumor.