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Background <p>Iron deficiency anemia (IDA) is a significant micronutrient deficiency that affects million worldwide. A crucial trace element, cobalt (Co), is involved in erythropoiesis and is a component of vitamin B<sub>12</sub> (cobalamin). The levels of Co in anaemic patients are not well documented.</p> Aim <p>This study was designed to evaluate the Co status in IDA patients by correlating with various biochemical markers.</p> Methods <p>At a tertiary care facility in North India, 166 subjects with IDA participated in this cross-sectional study. Parameters such as TSH, Co, vitamin B12 (VB12), Hepcidin, vitamin D (VD3), folate, iron markers and complete blood count (CBC) were measured.</p> Results <p>Data analysis showed that median Co was 0.6 (0.2–2.7) µg/L, and patients exhibited significantly low hemoglobin (Hb, 8.89 ± 1.73&#xa0;g/dL), ferritin {FER, 8.2 (5-14.6) ng/mL}, and VD3 {13.5 (8.9–22) ng/mL}. Noteworthy significant associations of Co with VD3 (<i>r</i> = 0.154,<i>p</i> = 0.0482), VB12 (<i>r</i> = 0.153,<i>p</i> = 0.0496), and total iron-binding capacity (TIBC; <i>r</i> = 0.182,<i>p</i> = 0.0188) was observed. However, parameters such as FER (<i>p</i> = 0.1260), Hb (<i>p</i> = 0.0952), didn’t showed any significant correlation with Co levels.</p> Conclusion <p>Co’s correlation with VB12, VD3, and TIBC implies that it is involved in iron and micronutrient metabolism, even if it had shown no significance with HB and FER. The possible role of Co in the pathophysiology of anaemia requires future investigation in retrospective trials.</p>

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Clinical Correlation of Cobalt with Vitamin B12, Vitamin D and Iron Deficiency Anemia

  • 期刊论文

  • 发表日期：

    2026年2月20日

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  • Mukul Aggarwal,
  • Nandini Dubey,
  • Satnam Singh,
  • Vishal Kumar Vishwakarma,
  • Arvind Kumar,
  • Maroof A. Khan,
  • Rajesh Sagar,
  • Raj Kanwar,
  • Arun Kumar,
  • Harlokesh Narayan Yadav

摘要

Background

Iron deficiency anemia (IDA) is a significant micronutrient deficiency that affects million worldwide. A crucial trace element, cobalt (Co), is involved in erythropoiesis and is a component of vitamin B12 (cobalamin). The levels of Co in anaemic patients are not well documented.

Aim

This study was designed to evaluate the Co status in IDA patients by correlating with various biochemical markers.

Methods

At a tertiary care facility in North India, 166 subjects with IDA participated in this cross-sectional study. Parameters such as TSH, Co, vitamin B12 (VB12), Hepcidin, vitamin D (VD3), folate, iron markers and complete blood count (CBC) were measured.

Results

Data analysis showed that median Co was 0.6 (0.2–2.7) µg/L, and patients exhibited significantly low hemoglobin (Hb, 8.89 ± 1.73 g/dL), ferritin {FER, 8.2 (5-14.6) ng/mL}, and VD3 {13.5 (8.9–22) ng/mL}. Noteworthy significant associations of Co with VD3 (r = 0.154,p = 0.0482), VB12 (r = 0.153,p = 0.0496), and total iron-binding capacity (TIBC; r = 0.182,p = 0.0188) was observed. However, parameters such as FER (p = 0.1260), Hb (p = 0.0952), didn’t showed any significant correlation with Co levels.

Conclusion

Co’s correlation with VB12, VD3, and TIBC implies that it is involved in iron and micronutrient metabolism, even if it had shown no significance with HB and FER. The possible role of Co in the pathophysiology of anaemia requires future investigation in retrospective trials.