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Background <p>The monocyte-to-high-density lipoprotein cholesterol ratio (MHR) is a marker of inflammation and cardiovascular risk in chronic kidney disease (CKD), but its role in hemodialysis (HD) adequacy remains unexplored.</p> Aim <p>To investigate the association between MHR and dialysis adequacy in HD patients.</p> Methods <p>In a cross-sectional study of 145 HD patients across three centers in Türkiye, pre-dialysis MHR was calculated, and dialysis adequacy was assessed using Kt/V (≤ 1.3 indicating inadequacy). Pearson’s correlation and Mann-Whitney U tests were used for analysis.</p> Results <p>Of 145 patients (51% female, mean age 53.2 ± 14.7 years), 30 (20.7%) have inadequate dialysis (Kt/V ≤ 1.3). MHR was higher in the inadequate dialysis group (17.1 ± 8.6 vs. 13.3 ± 5.6, <i>p</i> = 0.028) and inversely correlated with Kt/V (<i>r</i>=-0.23, <i>p</i> = 0.028). Female predominance was observed in the inadequate dialysis group (83.3% vs. 42.6%).</p> Conclusion <p>Higher MHR is associated with lower dialysis adequacy, suggesting its potential as a cost-effective biomarker for HD monitoring. Longitudinal studies are needed to validate these findings.</p>

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Monocyte to High-Density Lipoprotein Cholesterol Ratio Could be a Predictor of Dialysis Adequacy?

  • 期刊论文

  • 发表日期：

    2026年1月24日

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  • Mehmet Biricik,
  • Üstün Yılmaz

摘要

Background

The monocyte-to-high-density lipoprotein cholesterol ratio (MHR) is a marker of inflammation and cardiovascular risk in chronic kidney disease (CKD), but its role in hemodialysis (HD) adequacy remains unexplored.

Aim

To investigate the association between MHR and dialysis adequacy in HD patients.

Methods

In a cross-sectional study of 145 HD patients across three centers in Türkiye, pre-dialysis MHR was calculated, and dialysis adequacy was assessed using Kt/V (≤ 1.3 indicating inadequacy). Pearson’s correlation and Mann-Whitney U tests were used for analysis.

Results

Of 145 patients (51% female, mean age 53.2 ± 14.7 years), 30 (20.7%) have inadequate dialysis (Kt/V ≤ 1.3). MHR was higher in the inadequate dialysis group (17.1 ± 8.6 vs. 13.3 ± 5.6, p = 0.028) and inversely correlated with Kt/V (r=-0.23, p = 0.028). Female predominance was observed in the inadequate dialysis group (83.3% vs. 42.6%).

Conclusion

Higher MHR is associated with lower dialysis adequacy, suggesting its potential as a cost-effective biomarker for HD monitoring. Longitudinal studies are needed to validate these findings.