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Objectives <p> To explore the role of vinculin in the development of glomerulonephritis Q2R2.</p> Background <p> Vinculin is well-known for its specific role in stabilizing the adhesion between cells and the extracellular matrix (ECM), which regulates the strength of this adhesion in turn<b>.</b></p> Methods <p> A cross-sectional study was conducted involving 72 participants, who were categorized into two groups: 36 participants diagnosed with glomerulonephritis and 36 healthy participants as a control group. An enzyme-linked immunosorbent assay (ELISA) was used to analyze the serum vinculin levels in both groups.</p> Result <p> Compared to healthy controls, serum vinculin concentration in patients with glomerulonephritis was much higher (2246.7 ± 902.6 vs. 205.2 ± 191.2 P &lt; 0.001) with a positive correlation between vinculin levels in blood and urinary protein/creatinine ratio (p &lt; 0.05). In the case of glomerulonephritis, serum vinculin levels were, however, not found to be associated with any of the glomerulonephritis clinicopathological features.</p> Conclusion <p> Vinculin levels are significantly higher in blood serum in patients with glomerulonephritis and positively correlated with the progression of proteinuria. This poses a salient possibility for the role of vinculin in the development of glomerulonephritis. Further research into the molecular processes by which this protein may influence the development of glomerulonephritis might lead to improved clinical treatments and the development of new molecular therapeutics.</p>

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The Potential Role of Serum Vinculin as a Marker of Glomerulonephritis

  • 期刊论文

  • 发表日期：

    2026年3月10日

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  • Enas Said Essa,
  • Khaled Mohamed Amin Elzorkany,
  • Amira Samy Elmaghraby,
  • Anwaar M. Shaban,
  • Zeinab Abdelaziz Kasemy,
  • Heba E. Kasem

摘要

Objectives

To explore the role of vinculin in the development of glomerulonephritis Q2R2.

Background

Vinculin is well-known for its specific role in stabilizing the adhesion between cells and the extracellular matrix (ECM), which regulates the strength of this adhesion in turn.

Methods

A cross-sectional study was conducted involving 72 participants, who were categorized into two groups: 36 participants diagnosed with glomerulonephritis and 36 healthy participants as a control group. An enzyme-linked immunosorbent assay (ELISA) was used to analyze the serum vinculin levels in both groups.

Result

Compared to healthy controls, serum vinculin concentration in patients with glomerulonephritis was much higher (2246.7 ± 902.6 vs. 205.2 ± 191.2 P < 0.001) with a positive correlation between vinculin levels in blood and urinary protein/creatinine ratio (p < 0.05). In the case of glomerulonephritis, serum vinculin levels were, however, not found to be associated with any of the glomerulonephritis clinicopathological features.

Conclusion

Vinculin levels are significantly higher in blood serum in patients with glomerulonephritis and positively correlated with the progression of proteinuria. This poses a salient possibility for the role of vinculin in the development of glomerulonephritis. Further research into the molecular processes by which this protein may influence the development of glomerulonephritis might lead to improved clinical treatments and the development of new molecular therapeutics.