Scholarlink

Objective <p>The association between the <i>MnSOD Val16Ala</i> polymorphism and the development of diabetic nephropathy (DN) has yielded inconsistent results prompting the conduct of this meta-analysis.</p> Methods <p>We comprehensively searched four major electronic databases to identify studies containing genotypic data of the <i>MnSOD Val16Ala</i> polymorphism in type 2 diabetes mellitus (T2DM) and DN groups. Data were collected and analyzed using Review Manager 5.4.1 by calculating the odds ratios (ORs) and 95% confidence intervals (CIs).</p> Results <p>Twelve studies comprising 5,770 participants were analyzed. No significant association was found between the <i>MnSOD Val16Ala</i> polymorphism and DN risk across all genetic models, even after excluding outliers and restricting analyses to HWE-compliant studies. However, genotype distribution differed significantly between East and West Asian cohorts, with a higher frequency of the <i>Ala</i> allele among East Asian T2DM patients, suggesting possible population-specific genetic predisposition.</p> Conclusion <p>This meta-analysis does not provide conclusive evidence linking the <i>MnSOD Val16Ala</i> polymorphism to DN susceptibility in T2DM. Nevertheless, the observed ethnic differences in allele frequency may indicate a potential population-specific genetic risk, which requires confirmation through larger, multi-ethnic studies with standardized diagnostic criteria.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

No Association Between the MnSOD Val16Ala Polymorphism and Diabetic Nephropathy Risk in Type 2 Diabetes: A Meta-Analysis

  • 期刊论文

  • 发表日期：

    2025年12月29日

查看全文
  • Raphael Enrique Tiongco,
  • Mershen Gania,
  • Ma. Theresa Mae Doctora,
  • Stephanie Lois Sanchez,
  • Eliezer John Castro,
  • Ivy Cayabyab,
  • Angela Mae Cuartelon,
  • Michael John Dominguez,
  • John Ashley Flores

摘要

Objective

The association between the MnSOD Val16Ala polymorphism and the development of diabetic nephropathy (DN) has yielded inconsistent results prompting the conduct of this meta-analysis.

Methods

We comprehensively searched four major electronic databases to identify studies containing genotypic data of the MnSOD Val16Ala polymorphism in type 2 diabetes mellitus (T2DM) and DN groups. Data were collected and analyzed using Review Manager 5.4.1 by calculating the odds ratios (ORs) and 95% confidence intervals (CIs).

Results

Twelve studies comprising 5,770 participants were analyzed. No significant association was found between the MnSOD Val16Ala polymorphism and DN risk across all genetic models, even after excluding outliers and restricting analyses to HWE-compliant studies. However, genotype distribution differed significantly between East and West Asian cohorts, with a higher frequency of the Ala allele among East Asian T2DM patients, suggesting possible population-specific genetic predisposition.

Conclusion

This meta-analysis does not provide conclusive evidence linking the MnSOD Val16Ala polymorphism to DN susceptibility in T2DM. Nevertheless, the observed ethnic differences in allele frequency may indicate a potential population-specific genetic risk, which requires confirmation through larger, multi-ethnic studies with standardized diagnostic criteria.