Background <p>Right ventricular (RV) dysfunction (RVD) predicts adverse outcomes in heart failure with reduced ejection fraction (HFrEF) independent of left ventricular ejection fraction. Right ventricular index of myocardial performance (RIMP) is a combined measure of RV systolic and diastolic functions. We evaluated the relationship between RIMP and other indices of RV function in HFrEF patients attending a Nigerian tertiary hospital.</p> Methods <p>Eighty HFrEF and 80 age-and gender-matched healthy control subjects were enrolled. Echocardiographic indices: RIMP, Tricuspid annular plane systolic excursion (TAPSE), Right ventricular fractional area change (RVFAC), Tricuspid lateral annular systolic velocity (S’), Trans-tricuspid valve E wave deceleration time (TV-DT), Trans-tricuspid E to e´ ratio (TV-E/e’), and Trans-tricuspid E to A ratio (TV-EA) were assessed.</p> Results <p>The HFrEF subjects had a mean age of 54.74 ± 13.27 years and a median (IQR) LVEF of 34.0% (29–38%). The prevalence of RV systolic dysfunction in HFrEF subjects by RIMP, TAPSE, RVFAC, and S´ was 55% (<i>n</i> = 44), 60% (<i>n</i> = 48), 55% (<i>n</i> = 44), and 41.3% (<i>n</i> = 33), respectively. We found RV diastolic dysfunction in 70% (<i>n</i> = 56) of subjects with HFrEF. RIMP negatively correlated (<i>p</i> &lt; 0.05) with TAPSE, RVFAC, S´, and TV-DT, and positively correlated with TV-E/e´ (<i>p</i> &lt; 0.001). RIMP did not correlate with TV-E/A (<i>r</i> = 0.151, <i>p</i> = 0.18). None of these other indices of RVD predicted RIMP. (<i>p</i> &gt; 0.05).</p> Conclusion <p>RVD is common in HFrEF subjects. RIMP correlated with other indices of RVD, which however did not predict RIMP in these subjects. Ensuing longitudinal outcomes studies of Nigerian HF patients using RIMP are essential.</p>