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Background <p>Electrocardiogram (ECG)-detected left ventricular hypertrophy (LVH) is strongly linked with cardiovascular morbidity and mortality. The traditional ECG criteria for LVH have a relatively low sensitivity but Peguero-Lo Presti (PLP) ECG-LVH criterion has been shown in some studies to perform better. The aim is to test the diagnostic ability of the novel PLP ECG-LVH criterion among Nigerian hypertensives.</p> Methods <p>One hundred and eighty-three hypertensive patients who underwent ECG and ECHO were analyzed. Receiver operator characteristic (ROC) analysis, sensitivity, specificity, PPV, NPV, and accuracy of four ECG criteria: PLP, Cornell’s, modified Cornell’s and Sokolow-Lyon criteria were evaluated with echocardiogram LVH as the reference standard.</p> Results <p>Eighty-five (46.45%) had LVH among which 48 (26.23%) had eccentric hypertrophy (eLVH) and 37 (20.22%) had concentric LVH (cLVH). Of all the analyses, the PLP criterion obtained the best sensitivity and NPV rates, the Cornell’s and modified Cornell’s criteria showed greater specificity while the Cornell’s criteria showed greater PPV. The sensitivity values of all ECG criteria were highest among eLVH group and lowest in cLVH group. Cornell’s criterion had the highest AUC (AUC: 0.957; 95% CI, 0.927–0.987; <i>p &lt;</i> 0.001) and Sokolow-Lyon criterion had the lowest AUC. There was significant AUC difference between the PLP criterion and the Sokolow-Lyon criterion (<i>p</i> &lt; 0.001), and between PLP criterion and Cornell criterion (<i>p</i> = 0.02).</p> Conclusions <p>These findings suggest PLP criterion had superior discriminative ability for the detection of LVH, cLVH and eLVH via ECG due to its superior sensitivity and NPV rates among the study population.</p>

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Diagnostic Performance of Peguero Lo Presti Electrocardiographic Criteria for Echocardiographically Diagnosed Left Ventricular Hypertrophy in Nigerian Hypertensive Patients

  • 期刊论文

  • 发表日期：

    2025年12月19日

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  • Opeyemi Ezekiel Ojo,
  • Busayo Onafowoke Oguntola,
  • Olatunji Bukola Olaoye,
  • Pauleen Ayomide Ukpabio,
  • Toyin Obafemi

摘要

Background

Electrocardiogram (ECG)-detected left ventricular hypertrophy (LVH) is strongly linked with cardiovascular morbidity and mortality. The traditional ECG criteria for LVH have a relatively low sensitivity but Peguero-Lo Presti (PLP) ECG-LVH criterion has been shown in some studies to perform better. The aim is to test the diagnostic ability of the novel PLP ECG-LVH criterion among Nigerian hypertensives.

Methods

One hundred and eighty-three hypertensive patients who underwent ECG and ECHO were analyzed. Receiver operator characteristic (ROC) analysis, sensitivity, specificity, PPV, NPV, and accuracy of four ECG criteria: PLP, Cornell’s, modified Cornell’s and Sokolow-Lyon criteria were evaluated with echocardiogram LVH as the reference standard.

Results

Eighty-five (46.45%) had LVH among which 48 (26.23%) had eccentric hypertrophy (eLVH) and 37 (20.22%) had concentric LVH (cLVH). Of all the analyses, the PLP criterion obtained the best sensitivity and NPV rates, the Cornell’s and modified Cornell’s criteria showed greater specificity while the Cornell’s criteria showed greater PPV. The sensitivity values of all ECG criteria were highest among eLVH group and lowest in cLVH group. Cornell’s criterion had the highest AUC (AUC: 0.957; 95% CI, 0.927–0.987; p < 0.001) and Sokolow-Lyon criterion had the lowest AUC. There was significant AUC difference between the PLP criterion and the Sokolow-Lyon criterion (p < 0.001), and between PLP criterion and Cornell criterion (p = 0.02).

Conclusions

These findings suggest PLP criterion had superior discriminative ability for the detection of LVH, cLVH and eLVH via ECG due to its superior sensitivity and NPV rates among the study population.