Scholarlink

Introduction <p>Skull base chordomas are rare malignancies and account for less than 0.2% of all intracranial neoplasms. Several extensive population-based studies have estimated the overall incidence rate of chordomas to be approximately 0.8 per 1&#xa0;million population per year.</p> Case Presentation <p>We report the case of a 43-year-old woman with a history of hypertension and chronic opium inhalation who presented to the ophthalmic emergency department with bilateral blindness. She described a gradual decline in vision over two years, starting with blurred vision in the right eye, followed by right eye blindness one year prior, and left eye blindness several days before presentation. Examination showed bilateral proptosis, lid retraction, sluggish pupillary reactions, and no light perception in both eyes. The optic discs appeared atrophic bilaterally. Optical coherence tomography revealed significant loss of the retinal nerve fiber layer and ganglion cell complex. Neuroimaging identified a large mass involving the nasal, orbital, and suprasellar regions, and the patient was referred for neurosurgical evaluation. After surgical resection with a multidisciplinary team approach, histopathologic analysis confirmed the diagnosis of a clival chordoma. Post-operative imaging was performed to assess the extent of tumor removal.</p> Conclusion <p>This case highlights the importance of early neuro-ophthalmic assessment and neuroimaging in patients with unexplained progressive vision loss, as compressive optic neuropathy may result from rare skull base tumors such as chordoma.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

A Clival Chordoma Presented with Bilateral Visual Loss: A Case Report

  • 期刊论文

  • 发表日期：

    2025年11月29日

查看全文
  • Farid Shekarchian,
  • Mohammadreza Same,
  • Ehsan Keykhosravi,
  • Mehdi Bakhshai,
  • Ahmad Gharouni,
  • Mehrdad Motamed Shariati

摘要

Introduction

Skull base chordomas are rare malignancies and account for less than 0.2% of all intracranial neoplasms. Several extensive population-based studies have estimated the overall incidence rate of chordomas to be approximately 0.8 per 1 million population per year.

Case Presentation

We report the case of a 43-year-old woman with a history of hypertension and chronic opium inhalation who presented to the ophthalmic emergency department with bilateral blindness. She described a gradual decline in vision over two years, starting with blurred vision in the right eye, followed by right eye blindness one year prior, and left eye blindness several days before presentation. Examination showed bilateral proptosis, lid retraction, sluggish pupillary reactions, and no light perception in both eyes. The optic discs appeared atrophic bilaterally. Optical coherence tomography revealed significant loss of the retinal nerve fiber layer and ganglion cell complex. Neuroimaging identified a large mass involving the nasal, orbital, and suprasellar regions, and the patient was referred for neurosurgical evaluation. After surgical resection with a multidisciplinary team approach, histopathologic analysis confirmed the diagnosis of a clival chordoma. Post-operative imaging was performed to assess the extent of tumor removal.

Conclusion

This case highlights the importance of early neuro-ophthalmic assessment and neuroimaging in patients with unexplained progressive vision loss, as compressive optic neuropathy may result from rare skull base tumors such as chordoma.