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Purpose <p>Visual impairment significantly impacts global health, with an estimated 2.2 billion individuals affected worldwide, largely due to diabetic retinopathy (DR), age-related macular degeneration (AMD), and vein occlusions. Despite the rising prevalence of these conditions, there is limited national database on retinal disease patterns due to the lack of ophthalmic registries. The study aims to present epidemiological and clinical patterns of retinal diseases using baseline data from a multicenter hospital-based retinal registry established across various states in India.</p> Methods <p>A multicenter medical retinal registry (INDO-EYE) was established under the Biotechnology Industry Research Assistance Council (BIRAC) and the Department of Biotechnology (DBT) to collect data on common retinal diseases. Data was collected from 5,421 cases using standardized protocols, ensuring adherence to Good Clinical Practice (GCP) guidelines. Statistical analysis was performed using R version 4.4.1.</p> Results <p>The registry included 5,421 cases, with Diabetic Retinopathy (DR) most common (68%), followed by BRVO (15%), CRVO (9%), and AMD (12%). Mean age differed by condition: highest in AMD(65.1&#xa0;years), and lowest in DR (57.3&#xa0;years). Males predominated across all groups, particularly in DR (67.9%). Most common comorbidities were diabetes and hypertension. Behavioral factors showed alcohol use in 20% of DR cases, with lower rates in other conditions. Tobacco use was similar across groups, equally highest among DR and CRVO (26%). Most patients presented with hemorrhages and hard exudates. Nearly 50% of patients with DR presented with PDR. There was moderate impairment in vision among AMD, DR, and CRVO, with BRVO patients showing better presenting vision (Median BCVA 0.3 logMAR).</p> Conclusion <p>The registry findings provide information about demographic, clinical, and comorbidity profiles of retinal disease patients at presentation in India. These baseline data suggest that the patients already have comorbidities for a long period of time and they present late. This highlights the critical need for preventive and early therapeutic interventions, especially for diabetic retinopathy.</p>

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Presenting Patterns of Retinal Diseases in India: Findings from a Multicenter Hospital-Based Medical Retinal Registry (INDO-EYE Study)

  • 期刊论文

  • 发表日期：

    2025年10月27日

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  • Gopal S. Pillai,
  • Bibhuti Prassan Sinha,
  • Natarajan Sundaram,
  • Sheeba C. S,
  • Manabjyoti Barman,
  • Alok Sen,
  • Merin Dickson,
  • Ashid Salim,
  • Geethu Paul,
  • Manjisa Choudhury,
  • Aniket Kumar,
  • Poonam Jangid,
  • Anjana Abhilash

摘要

Purpose

Visual impairment significantly impacts global health, with an estimated 2.2 billion individuals affected worldwide, largely due to diabetic retinopathy (DR), age-related macular degeneration (AMD), and vein occlusions. Despite the rising prevalence of these conditions, there is limited national database on retinal disease patterns due to the lack of ophthalmic registries. The study aims to present epidemiological and clinical patterns of retinal diseases using baseline data from a multicenter hospital-based retinal registry established across various states in India.

Methods

A multicenter medical retinal registry (INDO-EYE) was established under the Biotechnology Industry Research Assistance Council (BIRAC) and the Department of Biotechnology (DBT) to collect data on common retinal diseases. Data was collected from 5,421 cases using standardized protocols, ensuring adherence to Good Clinical Practice (GCP) guidelines. Statistical analysis was performed using R version 4.4.1.

Results

The registry included 5,421 cases, with Diabetic Retinopathy (DR) most common (68%), followed by BRVO (15%), CRVO (9%), and AMD (12%). Mean age differed by condition: highest in AMD(65.1 years), and lowest in DR (57.3 years). Males predominated across all groups, particularly in DR (67.9%). Most common comorbidities were diabetes and hypertension. Behavioral factors showed alcohol use in 20% of DR cases, with lower rates in other conditions. Tobacco use was similar across groups, equally highest among DR and CRVO (26%). Most patients presented with hemorrhages and hard exudates. Nearly 50% of patients with DR presented with PDR. There was moderate impairment in vision among AMD, DR, and CRVO, with BRVO patients showing better presenting vision (Median BCVA 0.3 logMAR).

Conclusion

The registry findings provide information about demographic, clinical, and comorbidity profiles of retinal disease patients at presentation in India. These baseline data suggest that the patients already have comorbidities for a long period of time and they present late. This highlights the critical need for preventive and early therapeutic interventions, especially for diabetic retinopathy.