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Background <p>Sepsis is a major cause of illness and death in critically ill patients. Identifying reliable prognostic biomarkers as early as possible is essential to improve patient outcomes. The serum lactate-to-albumin (L/A) ratio has become a reliable sign of sepsis severity.</p> Objective <p>To assess the prognostic value of the L/A ratio in sepsis patients and its link to clinical outcomes such as the length of ICU and hospital stays, the need for ventilator support, hemodialysis, and in-hospital mortality.</p> Methods <p>A cross-sectional observational study took place between June 2023 and November 2024 at Justice K.S. Hegde Hospital. Seventy-two patients diagnosed with sepsis, according to SEPSIS-3 criteria, were included. Serum lactate and albumin levels at admission were recorded, and the L/A ratio was calculated. Correlations between the L/A ratio and clinical outcomes were assessed using appropriate statistical analyses including ROC curve evaluation.</p> Results <p>The mean age of patients was 61.75 ± 13.36&#xa0;years. Pneumonia (41.7%) and urinary tract infections (26.4%) were the predominant causes of sepsis. A higher L/A ratio was significantly associated with longer ICU stay, increased need for mechanical ventilation (AUC = 0.882), hemodialysis (AUC = 0.752), and higher mortality (AUC = 0.802). Non-survivors had a significantly elevated median L/A ratio compared to survivors.</p> Conclusion <p>The L/A ratio is a valuable prognostic biomarker in sepsis, correlating strongly with disease severity, organ support requirements, and mortality risk. Its routine assessment may aid in early risk stratification and informed clinical decision-making.</p>

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Prognostic Utility of the Lactate-to-Albumin Ratio in Sepsis: A Prospective Observational Cohort Study

  • 期刊论文

  • 发表日期：

    2025年10月10日

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  • Samjo M. George,
  • Ivor Peter D’Souza,
  • Anjusha Alex,
  • Nehal Kunjumoidu

摘要

Background

Sepsis is a major cause of illness and death in critically ill patients. Identifying reliable prognostic biomarkers as early as possible is essential to improve patient outcomes. The serum lactate-to-albumin (L/A) ratio has become a reliable sign of sepsis severity.

Objective

To assess the prognostic value of the L/A ratio in sepsis patients and its link to clinical outcomes such as the length of ICU and hospital stays, the need for ventilator support, hemodialysis, and in-hospital mortality.

Methods

A cross-sectional observational study took place between June 2023 and November 2024 at Justice K.S. Hegde Hospital. Seventy-two patients diagnosed with sepsis, according to SEPSIS-3 criteria, were included. Serum lactate and albumin levels at admission were recorded, and the L/A ratio was calculated. Correlations between the L/A ratio and clinical outcomes were assessed using appropriate statistical analyses including ROC curve evaluation.

Results

The mean age of patients was 61.75 ± 13.36 years. Pneumonia (41.7%) and urinary tract infections (26.4%) were the predominant causes of sepsis. A higher L/A ratio was significantly associated with longer ICU stay, increased need for mechanical ventilation (AUC = 0.882), hemodialysis (AUC = 0.752), and higher mortality (AUC = 0.802). Non-survivors had a significantly elevated median L/A ratio compared to survivors.

Conclusion

The L/A ratio is a valuable prognostic biomarker in sepsis, correlating strongly with disease severity, organ support requirements, and mortality risk. Its routine assessment may aid in early risk stratification and informed clinical decision-making.