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Purpose <p>Beta-3 adrenergic receptors play a significant role in regulating energy utilization and metabolism, lipid mobilization, and sensitivity of insulin. They are the most relevant target in metabolic disorders such as obesity, type 2 diabetes mellitus, and dyslipidemia. The B3 receptors are mainly present in brown adipose tissue, at where their activation increases thermogenesis through uncoupling protein 1, increasing energy expenditure, and in white adipose tissue, enhancing lipolysis in WAT, thus reducing fat accumulation.</p> Methodology <p>Using the databases PubMed, Google Scholar, Medline, and Embase, a systematic literature review was conducted. The data was collected by employing these databases providing the therapeutic role of beta-3 agonists in metabolic disorders. The articles were examined using Rayyan, an online tool, to ensure an efficient and thorough review process.</p> Results <p>The present review points towards the therapeutic role of stimulating β3-AR in metabolic syndromes, especially in PCOS, by enhancing insulin sensitivity, improving lipid metabolism, and dampening inflammation. β3-AR agonists promote thermogenesis and fat oxidation, contributing to weight control, an important determinant of PCOS management. Polymorphisms in ADRB3 in genetic studies affect metabolic responses, which hint at the possibility of tailored therapy.</p> Conclusion <p>In summary, β3-AR-targeted treatments have great potential to improve metabolic dysfunction in PCOS by tackling the major problems of inflammation, obesity, and insulin resistance. β3-AR agonists may represent a promising but still experimental avenue for managing metabolic dysfunction in PCOS. However, no clinical trials in women with PCOS have been conducted, and their potential role should be regarded as hypothesis-generating until validated by further clinical research.</p> Graphical Abstract <p></p>

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β3-Adrenergic Receptor Agonism: A Novel Therapeutic Strategy for Metabolic Dysfunction in Polycystic Ovary Syndrome

  • 期刊论文

  • 发表日期：

    2025年10月7日

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  • Bhawna Chhabra,
  • Gautam Saxena,
  • Aditya Srivastava,
  • Nakul Mahawar,
  • Havagiray Chitme

摘要

Purpose

Beta-3 adrenergic receptors play a significant role in regulating energy utilization and metabolism, lipid mobilization, and sensitivity of insulin. They are the most relevant target in metabolic disorders such as obesity, type 2 diabetes mellitus, and dyslipidemia. The B3 receptors are mainly present in brown adipose tissue, at where their activation increases thermogenesis through uncoupling protein 1, increasing energy expenditure, and in white adipose tissue, enhancing lipolysis in WAT, thus reducing fat accumulation.

Methodology

Using the databases PubMed, Google Scholar, Medline, and Embase, a systematic literature review was conducted. The data was collected by employing these databases providing the therapeutic role of beta-3 agonists in metabolic disorders. The articles were examined using Rayyan, an online tool, to ensure an efficient and thorough review process.

Results

The present review points towards the therapeutic role of stimulating β3-AR in metabolic syndromes, especially in PCOS, by enhancing insulin sensitivity, improving lipid metabolism, and dampening inflammation. β3-AR agonists promote thermogenesis and fat oxidation, contributing to weight control, an important determinant of PCOS management. Polymorphisms in ADRB3 in genetic studies affect metabolic responses, which hint at the possibility of tailored therapy.

Conclusion

In summary, β3-AR-targeted treatments have great potential to improve metabolic dysfunction in PCOS by tackling the major problems of inflammation, obesity, and insulin resistance. β3-AR agonists may represent a promising but still experimental avenue for managing metabolic dysfunction in PCOS. However, no clinical trials in women with PCOS have been conducted, and their potential role should be regarded as hypothesis-generating until validated by further clinical research.

Graphical Abstract