Introduction <p>Mental and substance-related disorders are common conditions. Individuals with these illnesses are more likely to be absent from work, often for extended periods of time, and can have lower productivity, which increases employee turnover, making it a prominent concern. Unemployment or prolonged time away from work can contribute to or exacerbate poor mental and physical health, whereas employment can positively impact well-being.</p> Methods <p>Literature searches were performed to&#xa0; examine the role of work as a source of well-being and a potential conduit to recovery from mental and substance-related disorders.</p> Results <p>The authors find that evidence suggests work is generally beneficial for health and recovery; however, these benefits depend on the qualities of work. A shift in workplace organization toward a destigmatized and user-centered approach that focuses on enhancing recovery and the health-promoting factors of work, such as a supportive environment, fair income, and benefits, is likely beneficial.</p> Conclusion <p>Work can be a valuable source of support for individuals in recovery from mental and substance-related conditions, and integrating recovery-friendly principles into a work environment is shown to promote health and is likely to benefit employers and employees.</p>