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Aim <p>Implementing a standardised National Health System (NHS) in the United Kingdom (UK) has promoted equitable healthcare access. This review aims to explore disparities in treatment outcomes for individuals with colorectal cancer (CRC) based on their race or ethnicity.</p> Methods <p>This prospectively registered review on the INPLASY database and a systematic search was conducted following PRISMA guidelines using EBSCO, Medline and EMBASE databases from inception to June 2024. Observational, experimental or qualitative studies reporting disparity in treatment outcomes for adult patients with CRC in the UK were included. Our primary outcomes included were survival rates and morbidity. Our secondary outcome was rate of surgery with curative intent. Studies reported or performed outside of the UK were excluded.</p> Results <p>Three retrospective cohort studies were identified (1992, 1995 and 2009). One study reported lower mortality from CRC in patients of Indian ethnicities born in India compared to their UK-born counterparts by 40%. One study reported East African males had a 30% lower risk of mortality compared to their UK-born counterparts. One study found no significant difference in 5-year survival outcomes between Caucasian and South Asian patients [<i>p</i> &gt; 0.05]. There was a larger number of Caucasian patients undergoing definitive surgical resection (72.8%) compared to the South Asian population (63%). One study reported a higher proportion of South Asian patients undergoing palliative surgery compared with Caucasian patients (14.2% vs 7.2%, respectively, <i>p</i> = 0.017].</p> Conclusion <p>Disparities in treatment outcomes within the UK remain under-explored. Robust national studies are needed to investigate disparities between different ethnic and racial groups in the UK.</p>

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Racial and Ethnic Disparities in Treatment Outcomes of Patients with Colorectal Cancer (CRC) in the UK: A Systematic Review

  • 期刊论文

  • 发表日期：

    2025年9月20日

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  • Omar Ezzat Saber Mostafa,
  • Shafquat Zaman,
  • Mark Robert Openshaw,
  • Akinfemi Akingboye

摘要

Aim

Implementing a standardised National Health System (NHS) in the United Kingdom (UK) has promoted equitable healthcare access. This review aims to explore disparities in treatment outcomes for individuals with colorectal cancer (CRC) based on their race or ethnicity.

Methods

This prospectively registered review on the INPLASY database and a systematic search was conducted following PRISMA guidelines using EBSCO, Medline and EMBASE databases from inception to June 2024. Observational, experimental or qualitative studies reporting disparity in treatment outcomes for adult patients with CRC in the UK were included. Our primary outcomes included were survival rates and morbidity. Our secondary outcome was rate of surgery with curative intent. Studies reported or performed outside of the UK were excluded.

Results

Three retrospective cohort studies were identified (1992, 1995 and 2009). One study reported lower mortality from CRC in patients of Indian ethnicities born in India compared to their UK-born counterparts by 40%. One study reported East African males had a 30% lower risk of mortality compared to their UK-born counterparts. One study found no significant difference in 5-year survival outcomes between Caucasian and South Asian patients [p > 0.05]. There was a larger number of Caucasian patients undergoing definitive surgical resection (72.8%) compared to the South Asian population (63%). One study reported a higher proportion of South Asian patients undergoing palliative surgery compared with Caucasian patients (14.2% vs 7.2%, respectively, p = 0.017].

Conclusion

Disparities in treatment outcomes within the UK remain under-explored. Robust national studies are needed to investigate disparities between different ethnic and racial groups in the UK.