Purpose <p>The main objective of the current study was to assess the quality of recovery (QoR) between patients who received total intravenous anesthesia (propofol) versus inhalational anesthesia (isoflurane) after undergoing elective laparoscopic cholecystectomy.</p> Design <p>Single-centre prospective observational study.</p> Methods <p>A total of 80 patients scheduled for elective laparoscopic cholecystectomy were divided into two groups: group A (TIVA) and group B (IHA). The primary outcome was the quality of recovery-15 (QoR-15) questionnaires at Postoperative day 1 POD-1 (24&#xa0;h) after surgery. Other data recorded included cognitive scores, pain scores, sedation and agitation scores, and&#xa0;post-anesthesia&#xa0;care unit (PACU) data.</p> Results <p>Eighty patients were enrolled and 78 patients completed the study. The QoR-15 scores and cognitive scores on POD-1 were found to be significantly higher in group B (IHA) compared with group A (TIVA) indicating quality recovery was faster in group B (IHA). This difference appeared to continue to POD-2, which is statistically significant. Pain scores at POD-1 and POD-2 were significantly lower in group B than in group A. Sedation and agitation scores during emergence were significantly lower in group B than in group A.</p> Conclusion <p>Group B (IHA) provides better QoR, cognitive scores, sedation, and lower pain scores in comparison to group A (TIVA) after surgery.</p>