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Background <p>Phosphatase and TENsin homolog (PTEN), a tumor suppressor, is a critical factor in regulating the phosphoinositide 3-kinase (PI3K) pathway to prevent excessive cell growth. Absence or alteration of PTEN expression is associated with poor prognosis of ovarian carcinomas. This systematic review and meta-analysis aim to investigate the relationship between PTEN status and ovarian cancer prognosis.</p> Method <p>A systematic literature search was conducted up to October 8, 2023, to find relevant articles from PubMed, Scopus, Web of Science, and Cochrane Library. Eligible studies were included. The meta-analysis was performed after data extraction and quality assessment.</p> Result <p>Seventeen studies with a total of 2395 women with ovarian cancer were included. The hazard ratio (HR) was defined as a measure of the predictive value of the risk of death for patients with PTEN-positive tumors. Analysis was performed based on overall survival (OS) and progression-free survival (PFS). A positive correlation was observed in both cases (OS: HR = 0.75, 95% CI = [0.54, 1.05]; PFS: HR = 0.87, 95% CI = [0.59, 1.28]); however, it was not significant. After adjusting the variables, this positive relationship remained insignificant (OS: HR = 0.89, 95% CI = [0.57, 1.41]; PFS: HR = 0.91, 95% CI = [0.41, 2.00]). Egger’s test, Begg’s test, and funnel plot showed no publication bias.</p> Conclusion <p>This systematic review and meta-analysis suggests a potential association between PTEN status and ovarian cancer prognosis; however, the findings were not statistically significant and should be interpreted with caution.</p>

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Association Between PTEN Status and Ovarian Cancer Prognosis: A Systematic Review and Meta-Analysis

  • 期刊论文

  • 发表日期：

    2025年8月11日

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  • Taif Haitham Al Saraireh,
  • Qumars Behfar,
  • Navid Rostami,
  • Faezeh Zakerinasab,
  • Parmida Seraj Ebrahimi,
  • Hadi Hashemi,
  • Arina Ansari,
  • Fariba Arbab Mojeni,
  • Amirhesam Amirbeik,
  • Elahe Ahsan,
  • Niloofar Deravi

摘要

Background

Phosphatase and TENsin homolog (PTEN), a tumor suppressor, is a critical factor in regulating the phosphoinositide 3-kinase (PI3K) pathway to prevent excessive cell growth. Absence or alteration of PTEN expression is associated with poor prognosis of ovarian carcinomas. This systematic review and meta-analysis aim to investigate the relationship between PTEN status and ovarian cancer prognosis.

Method

A systematic literature search was conducted up to October 8, 2023, to find relevant articles from PubMed, Scopus, Web of Science, and Cochrane Library. Eligible studies were included. The meta-analysis was performed after data extraction and quality assessment.

Result

Seventeen studies with a total of 2395 women with ovarian cancer were included. The hazard ratio (HR) was defined as a measure of the predictive value of the risk of death for patients with PTEN-positive tumors. Analysis was performed based on overall survival (OS) and progression-free survival (PFS). A positive correlation was observed in both cases (OS: HR = 0.75, 95% CI = [0.54, 1.05]; PFS: HR = 0.87, 95% CI = [0.59, 1.28]); however, it was not significant. After adjusting the variables, this positive relationship remained insignificant (OS: HR = 0.89, 95% CI = [0.57, 1.41]; PFS: HR = 0.91, 95% CI = [0.41, 2.00]). Egger’s test, Begg’s test, and funnel plot showed no publication bias.

Conclusion

This systematic review and meta-analysis suggests a potential association between PTEN status and ovarian cancer prognosis; however, the findings were not statistically significant and should be interpreted with caution.