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Background <p>Placental site trophoblastic tumor (PSTT) is a rare form of gestational trophoblastic neoplasia (GTN), making up &lt; 1–2% of GTN cases. Unlike other forms of GTD, such as hydatidiform mole or choriocarcinoma, PSTT is distinguished by its distinct pathological characteristics, slow progression, and relatively low levels of human chorionic gonadotropin (hCG) hormone.</p> Case Report <p>We are reporting an interesting case of a 25-year-old young lady with a short history of lower abdominal pain and reduced appetite for 15&#xa0;days. The patient had a prior history of amenorrhea for 11&#xa0;months, followed by a spontaneous abortion seven months back.</p> Results <p>Initial investigations revealed a positive urine pregnancy test, elevated β-hCG levels (1226&#xa0;IU/L), and pelvic ultrasound showing a large isoechoic lesion in the endometrial cavity. Magnetic resonance imaging findings suggested a uterine mass, initially suspected to be leiomyosarcoma. A biopsy, supported by immunohistochemistry, confirmed the diagnosis of PSTT.</p> Conclusions <p>This case highlights the diagnostic challenges of PSTT due to its rarity, nonspecific symptoms, and resemblance to other uterine malignancies. A multidisciplinary approach combining clinical, imaging, and pathological findings is essential for accurate diagnosis and treatment.</p>

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Placental Site Trophoblastic Tumor with Ambiguous Radiological Features; An Interesting Case Report with Review of Literature

  • 期刊论文

  • 发表日期：

    2025年7月23日

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  • Bhoomika Kaushik,
  • Rakesh Kumar Gupta,
  • Sarita Agrawal,
  • Amit Kumar

摘要

Background

Placental site trophoblastic tumor (PSTT) is a rare form of gestational trophoblastic neoplasia (GTN), making up < 1–2% of GTN cases. Unlike other forms of GTD, such as hydatidiform mole or choriocarcinoma, PSTT is distinguished by its distinct pathological characteristics, slow progression, and relatively low levels of human chorionic gonadotropin (hCG) hormone.

Case Report

We are reporting an interesting case of a 25-year-old young lady with a short history of lower abdominal pain and reduced appetite for 15 days. The patient had a prior history of amenorrhea for 11 months, followed by a spontaneous abortion seven months back.

Results

Initial investigations revealed a positive urine pregnancy test, elevated β-hCG levels (1226 IU/L), and pelvic ultrasound showing a large isoechoic lesion in the endometrial cavity. Magnetic resonance imaging findings suggested a uterine mass, initially suspected to be leiomyosarcoma. A biopsy, supported by immunohistochemistry, confirmed the diagnosis of PSTT.

Conclusions

This case highlights the diagnostic challenges of PSTT due to its rarity, nonspecific symptoms, and resemblance to other uterine malignancies. A multidisciplinary approach combining clinical, imaging, and pathological findings is essential for accurate diagnosis and treatment.