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<p>The use of biosensors in the field of bioanalysis and clinical diagnostics opens up new advanced functional possibilities for studying and understanding the processes occurring in living cells and makes it possible to actively influence their condition and functioning. These sensors can detect structural changes in DNA caused by UV irradiation and can be used to determine irradiation dose. The absorption of UV irradiation by DNA molecules with clearly expressed extremums at certain wavelengths of 220 and 260&#xa0;nm allows us to create sensitive and selective nanosized biosensors. The article discusses the mechanisms of current transfer and internal current noises, presents the results of calculations of dark current and photocurrent, responsivity, signal-to-noise ratio, and detectivity for a nanoscale biosensor based on the Au-thiol-DNA-thiol-Au structure. It is shown that with the selected parameters and incident irradiation power of 10 mW at a wavelength of 260&#xa0;nm, when the absorption coefficient of DNA is maximum and equal to <InlineEquation ID="IEq1"> <EquationSource Format="TEX">\(\:1.4\times\:{10}^{6}\)</EquationSource> </InlineEquation> cm<sup>−1</sup>, the photocurrent density can reach about nA/cm<sup>2</sup>, the sensitivity is up to 0.2 nA/W, the signal-to-noise ratio is about 250, and the detectivity reaches values of the order of 10<sup>10</sup> Jones. It is shown that the Au-DNA-Au structure can be used as a nanosensor for wavelengths of 220 and 260&#xa0;nm.For life science journals only (when applicable).</p>

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DNA-based UV Sensor

  • 期刊论文

  • 发表日期：

    2026年1月20日

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  • Ferdinand Gasparyan,
  • Lusine Gasparyan,
  • Vahan Simonyan

摘要

The use of biosensors in the field of bioanalysis and clinical diagnostics opens up new advanced functional possibilities for studying and understanding the processes occurring in living cells and makes it possible to actively influence their condition and functioning. These sensors can detect structural changes in DNA caused by UV irradiation and can be used to determine irradiation dose. The absorption of UV irradiation by DNA molecules with clearly expressed extremums at certain wavelengths of 220 and 260 nm allows us to create sensitive and selective nanosized biosensors. The article discusses the mechanisms of current transfer and internal current noises, presents the results of calculations of dark current and photocurrent, responsivity, signal-to-noise ratio, and detectivity for a nanoscale biosensor based on the Au-thiol-DNA-thiol-Au structure. It is shown that with the selected parameters and incident irradiation power of 10 mW at a wavelength of 260 nm, when the absorption coefficient of DNA is maximum and equal to \(\:1.4\times\:{10}^{6}\) cm−1, the photocurrent density can reach about nA/cm2, the sensitivity is up to 0.2 nA/W, the signal-to-noise ratio is about 250, and the detectivity reaches values of the order of 1010 Jones. It is shown that the Au-DNA-Au structure can be used as a nanosensor for wavelengths of 220 and 260 nm.For life science journals only (when applicable).