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<p><i>Persea macrantha</i>, an underexplored species, has gained scientific interest due to its diverse phytochemical composition and potential biological activities. In this study, various solvents (hexane, ethyl acetate, methanol and acetone) extract of <i>P. macrantha</i> leaf, bark, and root were prepared. The phytochemical composition of these extracts was analyzed using GC-MS and LC-MS/MS. Various nanoparticles (NPs), copper (PML-CuNPs, PMB-CuNPs, and PMR-CuNPs), zinc (PML-ZnNPs, PMB-ZnNPs, and PMR-ZnNPs), and selenium (PML-SeNPs, PMB-SeNPs, and PMR-SeNPs) were synthesised using <i>P. macrantha</i> leaf, bark, and root extracts (PM-NPs). The PM-NPs were characterised through various techniques, including UV-Visible spectrum, SEM, EDX, XRD, and FTIR. PM-NPs demonstrated antibacterial, antifungal, and anticancer efficacy. PMR-CuNPs demonstrated the largest inhibition zones against <i>E. coli</i> (28.0&#xa0;mm) and <i>S. aureus</i> (26.67&#xa0;mm). PMR-SeNPs exhibited the highest inhibition zones against <i>A. niger</i> (16.67&#xa0;mm) and <i>C. albicans</i> (17.0&#xa0;mm). The PMR-ZnNPs showed significant inhibition against <i>A. flavus</i> (17.67&#xa0;mm). The PML-ZnNPs (IC<sub>50</sub>=73.31&#xa0;µg/mL) and PMB-ZnNPs (IC<sub>50</sub>=52.52&#xa0;µg/ml) demonstrated the highest cytotoxicity, with significant effects on HT-29 and KB cells, respectively. The PMR-CuNPs (IC<sub>50</sub>=60.01&#xa0;µg/mL) showed greater effectiveness against KB cells, indicating their potential as promising anticancer agents. These findings emphasize the potential of PM-NPs for treating cancer and its secondary microbial infections.</p>

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Phytochemical Analysis and Biosynthesis of Various Nanoparticles from Persea macrantha Leaf, Bark, and Root Extracts for Treating Cancer and Microbial Infections

  • 期刊论文

  • 发表日期：

    2026年7月1日

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  • Kumudha Nanjunda Swamy,
  • Maya Cheluvaiah

摘要

Persea macrantha, an underexplored species, has gained scientific interest due to its diverse phytochemical composition and potential biological activities. In this study, various solvents (hexane, ethyl acetate, methanol and acetone) extract of P. macrantha leaf, bark, and root were prepared. The phytochemical composition of these extracts was analyzed using GC-MS and LC-MS/MS. Various nanoparticles (NPs), copper (PML-CuNPs, PMB-CuNPs, and PMR-CuNPs), zinc (PML-ZnNPs, PMB-ZnNPs, and PMR-ZnNPs), and selenium (PML-SeNPs, PMB-SeNPs, and PMR-SeNPs) were synthesised using P. macrantha leaf, bark, and root extracts (PM-NPs). The PM-NPs were characterised through various techniques, including UV-Visible spectrum, SEM, EDX, XRD, and FTIR. PM-NPs demonstrated antibacterial, antifungal, and anticancer efficacy. PMR-CuNPs demonstrated the largest inhibition zones against E. coli (28.0 mm) and S. aureus (26.67 mm). PMR-SeNPs exhibited the highest inhibition zones against A. niger (16.67 mm) and C. albicans (17.0 mm). The PMR-ZnNPs showed significant inhibition against A. flavus (17.67 mm). The PML-ZnNPs (IC50=73.31 µg/mL) and PMB-ZnNPs (IC50=52.52 µg/ml) demonstrated the highest cytotoxicity, with significant effects on HT-29 and KB cells, respectively. The PMR-CuNPs (IC50=60.01 µg/mL) showed greater effectiveness against KB cells, indicating their potential as promising anticancer agents. These findings emphasize the potential of PM-NPs for treating cancer and its secondary microbial infections.