<p>Rice bran acid oil and two different alcohols (methanol and butanol) were utilized to create the plasticizers used in this study from sustainable raw resources. Two samples of environmentally friendly plasticizer were acquired; their physicochemical characteristics and thermal stability (DSC analysis) were examined, and their chemical compositions were verified by infrared spectroscopy (FT–IR) investigations. The plasticization effectiveness of the resulting ester combinations was assessed when they were employed as poly (vinyl chloride) (PVC) plasticizers. Soft PVC’s mechanical characteristics were assessed at different plasticizer concentrations (0% to 3%). The developed plasticizers were found to have abundant mechanical and physical qualities as well as strong plasticization efficiency. The Universal Testing Machine (UTM) was used to measure the tensile strength, stiffness, elongation percentage, and Young’s modulus. The results showed that adding plasticizer from 0% to 3% improved the tensile and elongation characteristics. According to the research’ findings, synthetic epoxidized rice bran esters can offer a sustainable substitute for harmful plasticizers based on phthalates. In addition to these evaluations, the surface morphology of the synthesized epoxidized esters and their plasticized PVC films was further characterized using Field Emission Gun–Scanning Electron Microscopy (FEG-SEM), which confirmed uniform microstructural distribution and the absence of major defects. Furthermore, the migration and leaching behaviour of the plasticized films was investigated using solvents of varying polarity to assess extraction resistance. The migration study demonstrated that the butyl ester-based plasticizer exhibited comparatively lower solvent extraction and better stability within the PVC matrix. These additional analyses collectively reinforce the potential of epoxidized rice bran esters as efficient, stable, and environmentally benign alternatives to conventional phthalate-based plasticizers. </p>