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<p>Flavonols are a famous family of natural polyphenols, largely due to their significant properties in the medicinal field. Medicinal chemistry continues to converge on the construction of flavonoid skeletons, alongside the vast number of natural flavonoids. Consistent with expectations, the amplification of organic synthetic protocols represents a recognized avenue for acquiring abundant flavonoid scaffolds possessing specific pharmacological activities. This article summarizes the different synthetic strategies, biological activities, and SAR for flavonol derivatives from the past ten years, wishing to offer a wide-ranging retrospect and prospect concerning flavonol analogues.</p>

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A Decade of Progress: Synthesis, Bioactivity, and Structure–Activity Relationships of Flavonol Derivatives

  • 期刊论文

  • 发表日期：

    2026年4月28日

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  • Dorsaf Jebri,
  • Mansour Znati,
  • Hichem Ben Jannet

摘要

Flavonols are a famous family of natural polyphenols, largely due to their significant properties in the medicinal field. Medicinal chemistry continues to converge on the construction of flavonoid skeletons, alongside the vast number of natural flavonoids. Consistent with expectations, the amplification of organic synthetic protocols represents a recognized avenue for acquiring abundant flavonoid scaffolds possessing specific pharmacological activities. This article summarizes the different synthetic strategies, biological activities, and SAR for flavonol derivatives from the past ten years, wishing to offer a wide-ranging retrospect and prospect concerning flavonol analogues.