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<p>This study presents the development of an innovative pharmaceutical cream aimed at transforming topical wound care through a synergistic blend of bioactive natural extracts, oils, and hyaluronic acid (HA). The formulation was developed for industrial scalability using an oil-in-water (O/W) emulsification process via a rotor–stator homogenizer. Emulsion stability was evaluated across varying surfactant types and concentrations, supported by physicochemical characterization including rheology (viscosity and penetration resistance) and particle size distribution. Antioxidant activity and microbiological safety were assessed through standardized tests, including challenge testing in compliance with the European Pharmacopoeia. In vivo wound healing studies confirmed the therapeutic efficacy of the formulation. Results indicated that stable O/W emulsions required either Xalifin 15 at ≥ 6% or a balanced combination with PEG-8 Beeswax at ≤ 3%. Particle size analysis revealed a bimodal distribution, while viscosity testing demonstrated pseudoplastic behavior. Penetrometry analysis revealed that 5% decyl oleate offers the most favorable rheological profile. Antioxidant evaluation highlighted the hydrophilic nature of tincture-derived compounds, and preservative addition ensured microbiological stability. Overall, the formulation exhibited robust physicochemical and microbiological stability, with a proven synergistic effect between bioactive molecules and HA, enhancing wound healing potential.</p>

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Plant Extract-Enriched Hyaluronic Acid Emulsion for Wound Care

  • 期刊论文

  • 发表日期：

    2026年3月21日

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  • Souha Ben Mahmoud,
  • Rim Tlatli,
  • Yassine Mrabet,
  • Nedra Bennour,
  • Rim Dimassi,
  • Gazi Bekri,
  • Rafik Kalfat,
  • Haykel Galai,
  • Ramzi Boubaker Elandalousi,
  • Rim Driouich

摘要

This study presents the development of an innovative pharmaceutical cream aimed at transforming topical wound care through a synergistic blend of bioactive natural extracts, oils, and hyaluronic acid (HA). The formulation was developed for industrial scalability using an oil-in-water (O/W) emulsification process via a rotor–stator homogenizer. Emulsion stability was evaluated across varying surfactant types and concentrations, supported by physicochemical characterization including rheology (viscosity and penetration resistance) and particle size distribution. Antioxidant activity and microbiological safety were assessed through standardized tests, including challenge testing in compliance with the European Pharmacopoeia. In vivo wound healing studies confirmed the therapeutic efficacy of the formulation. Results indicated that stable O/W emulsions required either Xalifin 15 at ≥ 6% or a balanced combination with PEG-8 Beeswax at ≤ 3%. Particle size analysis revealed a bimodal distribution, while viscosity testing demonstrated pseudoplastic behavior. Penetrometry analysis revealed that 5% decyl oleate offers the most favorable rheological profile. Antioxidant evaluation highlighted the hydrophilic nature of tincture-derived compounds, and preservative addition ensured microbiological stability. Overall, the formulation exhibited robust physicochemical and microbiological stability, with a proven synergistic effect between bioactive molecules and HA, enhancing wound healing potential.