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<p>Isoflavonoids, a subclass of flavonoids, exhibit anti-cancer effects via plant defense and antioxidant mechanisms. These compounds are under investigation for their potential to inhibit cancer cell proliferation. They are known for their roles in plant defense and mammalian free radical scavenging. This review presents recent advancements in the development and evaluation of isoflavonoids and their hybrids as potential anticancer agents. Particular focus is given to their efficacy in in-vitro study against cancers of the stomach, liver, lung, breast, and prostate. It highlights their mechanisms of action through the modulation of key signaling pathways and inhibition of cell division. Several isoflavonoid-based hybrids have demonstrated notable in-vitro antitumor activity, underscoring their potential in drug development. Additionally, this review discusses the importance of structure–activity relationship (SAR) studies in guiding the rational design of isoflavonoid derivatives to enhance potency and selectivity. By consolidating recent findings, this review provides valuable insights into the therapeutic potential of isoflavonoids and outlines future research directions for their development as effective anticancer agents. </p>

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Therapeutic Potential of Isoflavonoids in Cancer Therapy: Comprehensive Insight into Biological Activities, Molecular Targets, and Structure–Activity Relationships

  • 期刊论文

  • 发表日期：

    2026年3月23日

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  • Rajesh R.,
  • Barath vaj M.,
  • Pronoy Kanti Das,
  • Prasad Sanjay Dhiwar,
  • Haripriya E.,
  • Devendra Reddy

摘要

Isoflavonoids, a subclass of flavonoids, exhibit anti-cancer effects via plant defense and antioxidant mechanisms. These compounds are under investigation for their potential to inhibit cancer cell proliferation. They are known for their roles in plant defense and mammalian free radical scavenging. This review presents recent advancements in the development and evaluation of isoflavonoids and their hybrids as potential anticancer agents. Particular focus is given to their efficacy in in-vitro study against cancers of the stomach, liver, lung, breast, and prostate. It highlights their mechanisms of action through the modulation of key signaling pathways and inhibition of cell division. Several isoflavonoid-based hybrids have demonstrated notable in-vitro antitumor activity, underscoring their potential in drug development. Additionally, this review discusses the importance of structure–activity relationship (SAR) studies in guiding the rational design of isoflavonoid derivatives to enhance potency and selectivity. By consolidating recent findings, this review provides valuable insights into the therapeutic potential of isoflavonoids and outlines future research directions for their development as effective anticancer agents.